The #9 Kentucky Wildcats will take on the #12 Louisville Cardinals on Tuesday, November 11, 2025, at 8:00 PM ET. The game will be held at the KFC Yum! Center in Louisville, KY, and will be broadcast on ESPN. This non-conference game features Kentucky from the Southeastern Conference and Louisville from the Atlantic Coast Conference. Louisville is favored with a spread of -4.5, while Kentucky is the underdog with a moneyline of +163.

Kentucky vs. Louisville Betting Prediction

• Spread Prediction: Kentucky +4.5. Kentucky has a strong start this season with a 2-0 record. They have a chance to cover the spread against Louisville.
• Over/Under Prediction: Over 175.5. Both teams have high-scoring offenses, with Louisville averaging 105 points per game and Kentucky at 92. This game could see a lot of points.

Team Trends

• The game will take place at KFC Yum! Center in Louisville, KY.
• Louisville Cardinals are the favorites with a spread of -4.5.
• Kentucky Wildcats have a moneyline of +163 as the underdogs.
• Both teams have a straight-up record of 2-0 in their last 3 games.
• The over/under for the game is set at 175.5.

Kentucky vs Louisville Preview

The Kentucky Wildcats and Louisville Cardinals are set to meet in a highly anticipated game. Both teams enter the game with perfect 2-0 records in the 2026 regular season. Kentucky is ranked #9 in the AP poll, while Louisville holds the #12 spot. The game will take place at the KFC Yum! Center in Louisville, KY, and fans can watch it live on ESPN.

This non-conference game features Kentucky from the Southeastern Conference and Louisville from the Atlantic Coast Conference. Louisville is the favorite with a spread of -4.5. Kentucky is the underdog with a moneyline of +163. Both teams are looking to continue their winning streaks and make a statement early in the season.

Louisville Cardinals: A Strong Start to the Season

The Louisville Cardinals have started their season with a perfect 2-0 record. They have won both games at home, showcasing their strength at the KFC Yum! Center. As they prepare to face the Kentucky Wildcats, they aim to continue their winning streak. Offensively, the Cardinals have been impressive, scoring an average of 105 points per game. They rank high in possessions per game, ensuring they have plenty of opportunities to score. Their field goal percentage is strong, with an effective field goal percentage of 61.2%. Key players like Ryan Conwell and Khani Rooths have contributed significantly to the team’s success. Conwell averages 15.5 points per game, while Rooths leads with 18 points per game. The Cardinals will rely on their solid roster to maintain their momentum against Kentucky.

Kentucky Wildcats: Ready for the Road Challenge

The Kentucky Wildcats are entering the season with a 2-0 record. They have yet to play an away game, making this matchup against Louisville their first test on the road. Ranked #9, the Wildcats are part of the Southeastern Conference. Offensively, the Wildcats average 92 points per game. They have a solid field goal percentage of 50.8%. The team is strong in rebounding, pulling down 50.5 rebounds per game, which ranks them 14th nationally. Key players like Otega Oweh and Collin Chandler are crucial for Kentucky. Oweh averages 14 points and 4 rebounds per game. Chandler contributes with 14.5 points and 3.5 rebounds per game.

Final Betting Pick

Kentucky’s spread of +4.5 looks promising. They have a strong start this season with a 2-0 record. Their offense scores 92 points per game, which can help them stay close to Louisville.

The over 175.5 is a solid pick due to both teams’ scoring abilities. Louisville averages 105 points per game, and Kentucky scores 92. With both teams having high-scoring offenses, the total points could easily go over 175.5.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.