The Louisville Cardinals, ranked #6, will take on the Cincinnati Bearcats on Friday, November 21, 2025, at 6:30 PM ET. The game will be held at the Heritage Bank Center in Cincinnati, OH, which is a neutral site. This non-conference game will be shown on ESPN2, with the Cardinals as the favorite. The Cardinals have a spread of -8.5, while the Bearcats have a spread of +8.5.

Louisville vs. Cincinnati Betting Prediction

• Spread Prediction: Cincinnati +8.5. Cincinnati has a strong record and plays at a neutral site, which could help them cover the spread.
• Over/Under Prediction: Over 162.5. Louisville scores a lot of points per game, and their games often go over the total.

Team Trends

• The game is at a neutral site, Heritage Bank Center in Cincinnati, OH.
• Louisville Cardinals are favored with a spread of -8.5.
• Cincinnati Bearcats have a moneyline of +322.
• Louisville has a 100% straight-up record in their last 10 games.
• Cincinnati has a 0% over/under record in their last 3 games.

Louisville vs Cincinnati Preview

The Louisville Cardinals are set to meet the Cincinnati Bearcats in a non-conference game at the Heritage Bank Center. Louisville comes into this game with an unbeaten record of 4-0 this season. They have shown strong performances, including a recent win over the Ohio Bobcats by 25 points. Key players like Ryan Conwell and Mikel Brown Jr. have been instrumental in their success, contributing significantly in points and assists.

The Cincinnati Bearcats also hold a 4-0 record this season. They recently secured a win against Mount St. Mary’s by 17 points. Baba Miller and Day Day Thomas have been key contributors for the Bearcats, with strong performances in scoring and rebounds. Both teams are looking to maintain their winning streaks in this exciting matchup.

Cincinnati Bearcats: Strong Start at Home

The Cincinnati Bearcats have started the season with a perfect 4-0 record. All wins came at home, showing their strength in familiar territory. They have yet to play an away game this season. In their recent game against Mount St. Mary’s, Cincinnati won 72-55. Baba Miller and Moustapha Thiam both scored 13 points and grabbed double-digit rebounds. Day Day Thomas led the team with 16 points and five assists. Cincinnati is averaging 78.5 points per game. They have a high number of possessions per game, ranking 17th nationally. However, their field goal percentage is 44.3%, which they might want to improve.

Louisville Cardinals: High-Scoring Offense

The Louisville Cardinals have a 4-0 record this season. They have played all their games at home, similar to Cincinnati. Their offense is strong, scoring 103 points per game, which ranks 2nd in the nation. Louisville’s shooting is impressive with a field goal percentage of 50%. They are also efficient from beyond the arc, making 12.8 three-pointers per game. Their effective field goal percentage stands at 59.4%, showing their shooting accuracy. Key players include Mikel Brown Jr. and Ryan Conwell. Brown Jr. averages 19.2 points and 27 assists over four games. Conwell contributes 19.2 points per game and adds depth to their lineup.

Final Betting Pick

Cincinnati at +8.5 is a solid pick because they have a strong record and play at a neutral site. Both teams are undefeated, which suggests a competitive game. Cincinnati’s ability to score and their decent rebounding stats could help them keep the game close.

The over 162.5 is also a good choice given Louisville’s high-scoring offense. They average 103 points per game, which is among the best in the country. With both teams playing at a fast pace, there is potential for a high-scoring game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.