The Notre Dame Fighting Irish will take on the #3 Houston Cougars on Wednesday, November 26, 2025, at 3:30 PM ET. This non-conference game will be held at the MGM Grand Garden Arena in Las Vegas, NV. Fans can catch the action on TNT as the Fighting Irish from the Atlantic Coast Conference face the Big 12’s Cougars in this exciting matchup.

Notre Dame vs. Houston Betting Prediction

• Spread Prediction: Notre Dame +10.5. Notre Dame has a decent record and is playing at a neutral site, which could help them cover the spread against Houston.
• Over/Under Prediction: Over 134.5. Houston’s recent games have consistently hit the over, making the over a good choice for this game.

Team Trends

• The game between Notre Dame and Houston will be held at a neutral site in Las Vegas.
• Notre Dame is a +10.5 underdog against Houston in this game.
• Notre Dame has won 71.4% of their games this season but has not won as an underdog.
• Houston has won 85.7% of their games and is 4-1 as a favorite this season.
• The over/under for the game is set at 134.5 points.

Notre Dame vs Houston Preview

The Notre Dame Fighting Irish are set to play against the #3 Houston Cougars in Las Vegas. The Fighting Irish have a 5-2 record this season. They recently won against the Rutgers Scarlet Knights, scoring 68 points. Markus Burton was a standout player with 21 points and 6 rebounds in that game.

The Houston Cougars come into this game with a 6-1 record. They are ranked #3 in the AP poll. In their last game, they lost to the Tennessee Volunteers by 3 points. Kingston Flemings scored 25 points and grabbed 4 rebounds in that matchup. The Cougars will look to bounce back against Notre Dame.

Houston Cougars: High Hopes and Strong Performance

The Houston Cougars have a 6-1 record this season. They have played well at home with a 4-1 record. On the road, they are undefeated with a 2-0 record. In their recent game, the Cougars lost to Tennessee by 3 points. Kingston Flemings scored 25 points and played 32 minutes. Milos Uzan added 17 points and 4 assists. Emanuel Sharp leads the team in scoring with 16.3 points per game. Kingston Flemings follows with 17.3 points per game. Chris Cenac Jr. is strong on the boards with 8.6 rebounds per game.

Notre Dame Fighting Irish: Ready for the Challenge

The Notre Dame Fighting Irish have a 5-2 record this season. They have performed well at home with a 5-1 record. However, they have struggled on the road, losing their only away game. Markus Burton is a key player for the Fighting Irish. He averages 20.3 points per game and has a strong shooting percentage of 51.0%. Jalen Haralson also contributes with 13.0 points per game. Notre Dame’s recent games show mixed results. They won against Rutgers by 5 points but lost to Kansas by 10 points. The team averages 78.1 points per game and has a field goal percentage of 47.9%.

Final Betting Pick

Notre Dame has a record of 5-2, which shows they can compete. Playing at a neutral site like the MGM Grand Garden Arena might help them stay close to Houston. The spread of +10.5 gives Notre Dame a good chance to cover, especially since they have a decent scoring average of 78.1 points per game.

Houston’s games often go over the total points line. They average 76.1 points per game, and their games have been high-scoring. With both teams having solid offensive stats, the over 134.5 points seems like a good pick. This game could easily see both teams scoring well, leading to a total over 134.5.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.