Syracuse Orange vs Iowa State Cyclones NCAAB Betting Prediction
PublishedNovember 26, 2025,            Posted By: Maria Uebelhor
Last updated:November 26, 2025 ,

NCAAB Syracuse Orange vs Iowa State Prediction 11/26

The Syracuse Orange will take on the #15 Iowa State Cyclones on Wednesday, November 26, 2025, at 1:00 PM ET. This non-conference game will be held at the MGM Grand Garden Arena in Las Vegas, NV. Fans can catch the action live on TNT as the Orange, with a 4-2 record, face the undefeated Cyclones, who stand at 6-0 this season.

Syracuse vs. Iowa State Betting Prediction

  • Spread Prediction: Syracuse +8.5. Syracuse has covered the spread in 60% of their last five games. They have shown they can keep games close even as underdogs.
  • Over/Under Prediction: Over 158.5. Iowa State averages 90.5 points per game, and the over has hit in 80% of their last five games. This suggests a high-scoring game.

Team Trends

  • The game between Syracuse Orange and #15 Iowa State Cyclones will be held at the MGM Grand Garden Arena in Las Vegas, a neutral site.
  • Syracuse Orange has a spread of +8.5, while Iowa State Cyclones has a spread of -8.5.
  • Syracuse Orange has won 66.7% of their last 10 games straight up.
  • Iowa State Cyclones have won 100% of their games straight up this season.
  • The over/under for the game is set at 158.5.

Syracuse vs Iowa State Preview

The Syracuse Orange are set to meet the #15 Iowa State Cyclones on Wednesday, November 26, 2025. The game will take place at the MGM Grand Garden Arena in Las Vegas, NV. Syracuse enters the game with a 4-2 record, having recently lost to Kansas and Houston.

Iowa State remains undefeated at 6-0, coming off a strong win against Creighton. The Cyclones have shown consistent performance, with key players like Joshua Jefferson leading the charge. Fans can watch the game live on TNT at 1:00 PM ET.

Iowa State Cyclones: Strong Start to the Season

The Iowa State Cyclones are ranked #15 in the nation. They play in the Big 12 Conference. So far, they have a perfect 6-0 record this season. The Cyclones have been strong at home, winning all five games. They also won their only away game. Their recent win against Creighton was by 18 points, with a score of 78-60. Joshua Jefferson is a key player for the Cyclones. He averages 18.3 points and 8.2 rebounds per game. Tamin Lipsey also contributes with 18.4 points per game.

Syracuse Orange: Road Challenges Await

The Syracuse Orange have a 4-2 record this season. They have played all their games at home so far. Their upcoming game against Iowa State will be their first away game. Syracuse recently lost two home games. They lost to Kansas by 11 points and to Houston by 4 points. In both games, their shooting percentages were below their season average. Key players for Syracuse include J.J. Starling and William Kyle III. Starling averages 8 points per game, while Kyle III scores 10 points per game. Both players contribute on the boards, with Kyle III averaging 9 rebounds per game.

Final Betting Pick

Syracuse has been effective at covering the spread, doing so in 60% of their last five games. Their ability to keep games close makes the +8.5 spread appealing. Although Syracuse is the underdog, they have shown they can compete against stronger teams.

The over/under line is set at 158.5, and the over looks promising. Iowa State scores 90.5 points per game, and the over has hit in 80% of their last five games. This suggests that both teams can contribute to a high-scoring game.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.