Boston College Eagles vs Louisville Cardinals NCAAF Betting Prediction
PublishedOctober 21, 2025,            Posted By: Maria Uebelhor
Last updated:October 21, 2025 ,

NCAAF Boston College Eagles vs Louisville Prediction 10/25

The Boston College Eagles will visit the Louisville Cardinals on Saturday, October 25, 2025. The game will take place at L&N Federal Credit Union Stadium in Louisville, KY, and it is set to kick off at 7:30 PM. Fans can catch the action on ACCN. This Week 9 matchup features the Eagles with a 1-6 record against the Cardinals, who stand at 5-1 this season.

Boston College vs. Louisville Betting Prediction

  • Money Line Prediction: Louisville Cardinals -3389. Louisville has a strong home record at 3-1 this season. Boston College has struggled on the road with a 0-3 record.
  • Over/Under Prediction: Over 55.5 (-106). Both teams have shown trends towards higher scoring games. Boston College games have gone over in 10 of their last 13 games.

Team Trends

  • Boston College Eagles have a road record of 0-3 this season.
  • Louisville Cardinals have a home record of 3-1 this season.
  • Boston College Eagles rank 28th in passing yards with 1,907 yards this season.
  • Louisville Cardinals are ranked 19th in the AP Poll and 22nd in the Coaches Poll.
  • Louisville Cardinals’ defense has recovered 3 fumbles, ranking 7th this season.

Boston College vs Louisville Preview

The Boston College Eagles are set to take on the Louisville Cardinals in a Week 9 game at L&N Federal Credit Union Stadium. The Eagles are struggling this season with a 1-6 record and are looking to break a six-game losing streak. They have yet to win a game on the road and are eager to secure their first away victory. Their conference record stands at 0-4, and they are at the bottom of the standings.

The Louisville Cardinals, on the other hand, have had a strong start to their season with a 5-1 record. They are currently ranked 19th in the AP Poll and 22nd in the Coaches Poll. The Cardinals have been solid at home with a 3-1 record and are on a one-game win streak. With a conference record of 2-1, they are in the top half of the standings. The Cardinals will aim to keep their momentum going against the Eagles.

Louisville Cardinals Overview

The Louisville Cardinals hold the #19 spot in the AP rankings and #22 in the Coaches Poll. They play in the Atlantic Coast Conference and call the L&N Federal Credit Union Stadium home. Their current season record stands at 5-1, with a home record of 3-1.

Quarterback Miller Moss leads the team with 1,606 passing yards and 9 touchdowns in 6 games. Running back Isaac Brown has rushed for 447 yards and scored 3 touchdowns over 6 games. Wide receiver Chris Bell is a top performer with 44 receptions, 638 receiving yards, and 6 touchdowns.

The Cardinals have scored 204 points this season, ranking 45th in points for. Their defense has allowed 126 points, ranking 64th in points against, while recording 14 sacks and 10 interceptions. Louisville is favored by 25.5 points in their upcoming home game, with the total set at 55.5 points.

Boston College Eagles: Aiming for Improvement

Boston College Eagles are part of the Atlantic Coast Conference. They play home games at Alumni Stadium in Massachusetts. This season, the Eagles have struggled with a 1-6 overall record and have not won on the road.

Quarterback Dylan Lonergan has been a key player for the Eagles. He has thrown for 1,394 yards with 9 touchdowns over 6 games. Running back Turbo Richard has contributed with 431 rushing yards and 5 touchdowns in 7 games.

On the defensive side, the Eagles have allowed 237 points, ranking 123rd in points against. They have recorded 12 sacks and 4 interceptions. Injuries are a concern, with several players listed as questionable for the upcoming game.

Final Betting Pick

The money line prediction for Louisville Cardinals at -3389 is strong. Louisville has a good home record of 3-1 this season. Boston College struggles on the road with a 0-3 record, making it hard for them to win away games.

The over/under prediction is set at over 55.5. Boston College games have gone over in 10 of their last 13 games. Both teams tend to play in high-scoring games, which supports the over pick. This trend makes the over 55.5 a reasonable choice for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.