The Illinois Fighting Illini take on the Purdue Boilermakers in Week 6 of the 2025 regular season. The game is set for Saturday, October 4, 2025, at 12:00 PM at Ross-Ade Stadium in West Lafayette, IN. Fans can catch the action on BTN as Illinois, ranked #22, aims to improve their 4-1 record, while Purdue looks to build on their 2-2 start.

Illinois vs. Purdue Betting Prediction

• Money Line Prediction: Illinois Fighting Illini -360. Illinois is ranked #22 and has a strong record of 4-1. They have been successful as favorites in their last 8 games.
• Over/Under Prediction: Over 57.0. Both teams have shown the ability to score, and Illinois games have gone over in their last 4 away games.

Team Trends

• Illinois Fighting Illini are ranked #22 in both the AP and Coaches Polls.
• Illinois has a road record of 1-1 this season.
• Purdue Boilermakers have a home record of 2-1 this season.
• Illinois won their last postseason game against South Carolina in the Cheez-It Citrus Bowl, 21-17.
• Purdue’s defense has recorded 10 sacks this season, ranking 11th overall.

Illinois vs Purdue Preview

The Illinois Fighting Illini are coming into this game with a strong 4-1 record. They are ranked #22 in both the AP and Coaches Polls. Illinois will try to keep their momentum going after a recent win. They have been solid at home, but their road performance is mixed with a 1-1 record. Their conference record is also 1-1, so they will be looking to improve that in this game.

Purdue Boilermakers have had a balanced start with a 2-2 record. They have played well at home with a 2-1 record, but they are on a two-game losing streak. Their conference record is 0-1, and they are unranked. Playing at Ross-Ade Stadium could give them an edge as they aim to get back on track in the Big Ten. Both teams are part of the same conference, making this game important for standings.

Purdue Boilermakers: Key Players and Stats

The Purdue Boilermakers play in the Big Ten Conference and their home games are held at Ross-Ade Stadium. This season, their record is 2-2, with a home record of 2-1. The team recently faced a tough loss against Notre Dame, with a score of 56-30.

Quarterback Ryan Browne has shown strong performances, leading the team with 1,036 passing yards and six touchdowns across four games. Running back Devin Mockobee stands out with 246 rushing yards and three touchdowns. On the receiving end, Nitro Tuggle leads with 196 receiving yards and three touchdowns.

Defensively, the Boilermakers have allowed 106 points this season, ranking 73rd. They have recorded ten sacks, placing them 11th in this category. The team has struggled with interceptions, having not recorded any yet this season.

Illinois Fighting Illini: Road Warriors on the Rise

Illinois Fighting Illini hold a 4-1 record this season. They are ranked #22 in both the AP and Coaches Polls. Their last game was a close 34-32 victory over USC.

Luke Altmyer is the top quarterback for Illinois. He has 1,183 passing yards and 11 touchdowns over five games. He has not thrown any interceptions this season.

Kaden Feagin leads the running backs with 300 rushing yards and three touchdowns. Receiver Hank Beatty has 383 receiving yards and one touchdown. Defensively, Illinois has 12 sacks and two interceptions, showing strong performance on that side of the field.

Final Betting Pick

Illinois is a strong pick for the money line at -360. They have a solid 4-1 record and are ranked #22. Their recent success as favorites in the last 8 games gives confidence in their ability to win. On the road, Illinois has shown they can perform well, with a 1-1 record this season, including a win against Duke.

The over/under prediction of over 57.0 is reasonable. Both teams have shown they can score points. Illinois games have gone over in their last 4 away games. Purdue’s games have also seen high scores, especially at home. This trend suggests that a high-scoring game is likely. The stats support the over pick, making it a good choice for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.