On Saturday, September 6, 2025, the Iowa Hawkeyes will play against the Iowa State Cyclones at Jack Trice Stadium in Ames, IA. This Week 2 game of the 2025 Regular Season kicks off at 12:00 PM and will be broadcast on FOX. The Hawkeyes enter with a 1-0 record, while the Cyclones hold a 2-0 record.

Iowa vs. Iowa State Betting Prediction

• Money Line Prediction: Iowa State Cyclones at -154. Iowa State has a strong home record of 2-0 this season. They are ranked #22 in the AP poll and have shown a strong offensive performance.
• Over/Under Prediction: Under 41.5. Iowa’s defense has only allowed 7 points this season, and both teams have strong defensive stats, suggesting a low-scoring game.

Team Trends

• The Iowa Hawkeyes are starting their road games for the 2025 season with a 0-0 road record.
• Iowa State Cyclones hold a perfect 2-0 home record for the 2025 season.
• Iowa State ranks 2nd in points scored this season with 79 points.
• Iowa Hawkeyes’ defense is ranked 4th in points against, allowing only 7 points this season.
• The game will be played at Jack Trice Stadium, home of the Iowa State Cyclones, on September 6, 2025.

Iowa vs Iowa State Preview

The Iowa Hawkeyes are set for their first road game of the season against the Iowa State Cyclones. The Hawkeyes are coming off a win at home and aim to continue their success. In the Big Ten, they have yet to start conference play, but a win here would be a good boost.

The Cyclones have started strong with a perfect home record. They are ranked 22nd in the AP Poll and 21st in the Coaches Poll. With a win streak of two games, they look to maintain their momentum. Playing at Jack Trice Stadium gives them a familiar setting to face the Hawkeyes.

Iowa State Cyclones: Season Overview and Key Players

Iowa State Cyclones are ranked #22 in the AP poll and #21 in the Coaches Poll. They play in the Big 12 Conference and call Jack Trice Stadium their home. This season, the team has a perfect record of 2-0, with both wins at home.

Rocco Becht leads the Cyclones as their top quarterback. He has thrown for 461 yards and 5 touchdowns in 2 games. Dylan Lee is a top running back with 81 rushing yards and 1 touchdown in his first game.

Brett Eskildsen stands out as a wide receiver with 5 receptions and 123 receiving yards. On defense, the Cyclones have allowed 28 points and recorded 2 sacks. They have also secured 2 interceptions and 2 fumbles recovered, ranking high in these areas.

Iowa Hawkeyes: Season Preview and Key Players

The Iowa Hawkeyes play in the Big Ten Conference and have their home games at Kinnick Stadium. They started the season strong with a 1-0 record, winning their only home game so far. In their last postseason game, the Hawkeyes faced the Missouri Tigers in the TransPerfect Music City Bowl, where they were defeated 27-24.

Mark Gronowski is the top quarterback for the Hawkeyes, with 44 passing yards and 1 touchdown in the first game. Xavier Williams leads the running backs with 122 rushing yards and 1 touchdown. Kaden Wetjen, a wide receiver, caught 1 pass for 2 yards and 1 touchdown.

On defense, the Hawkeyes allowed only 7 points in their season opener, ranking them 4th in points against. They recorded 2 sacks, also placing them high in this category. However, they did not secure any interceptions or fumble recoveries in their first game.

Final Betting Pick

Iowa State Cyclones have a strong home record. They are 2-0 at Jack Trice Stadium this season. Their offense is ranked 2nd in points scored, showing they can put up numbers. The Cyclones are ranked #22 in the AP poll, adding to their confidence at home. This makes the money line of -154 a solid choice.

The under 41.5 is a good pick due to both teams’ strong defenses. Iowa has only allowed 7 points this season, ranking 4th in points against. Iowa State’s defense is also solid, ranked 21st in points against. These stats suggest a low-scoring game, making the under a smart bet.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.