The Iowa State Cyclones will take on the Oklahoma State Cowboys in Week 14 of the 2025 regular season. The game is set for Saturday, November 29, 2025, at 12:00 PM and will be played at Boone Pickens Stadium in Stillwater, OK. Fans can catch the action on ESNU.

Iowa State vs. Oklahoma State Betting Prediction

• Money Line Prediction: Iowa State at -609. Iowa State has a strong record after a win, going 14-3 in their last 17 games. Oklahoma State has struggled at home with a 1-5 record this season.
• Over/Under Prediction: Under 47.5. Both teams have shown lower scoring in recent games, and Oklahoma State’s defense has been holding opponents to fewer points in their last few games.

Team Trends

• Iowa State Cyclones have a road record of 2-2 this season.
• Oklahoma State Cowboys have a home record of 1-5 this season.
• Iowa State Cyclones won their last game against Kansas Jayhawks with a score of 38-14.
• Oklahoma State Cowboys lost their last home game against Kansas State Wildcats with a score of 14-6.
• Iowa State Cyclones have a conference record of 4-4 in the Big 12.

Iowa State vs Oklahoma State Preview

The Iowa State Cyclones head into this game with a 7-4 record. They have a balanced performance in the Big 12 with a 4-4 conference record. The Cyclones are on a two-game win streak, which gives them momentum. They are looking to finish the regular season strong.

On the other hand, the Oklahoma State Cowboys have struggled this season, holding a 1-10 record. They have not won a conference game, standing at 0-8. The Cowboys are on a ten-game losing streak and hope to turn things around in front of their home crowd at Boone Pickens Stadium.

Oklahoma State Cowboys: Season Overview

The Oklahoma State Cowboys play in the Big 12 conference. They host games at Boone Pickens Stadium. This season, their record stands at 1-10, with a home record of 1-5.

The Cowboys have seen a tough season, with a conference record of 0-8. Their offense has scored 157 points, ranking 109th. On defense, they have allowed 380 points, ranking 146th.

Top quarterback Zane Flores has played 8 games and passed for 1,288 yards. Running back Rodney Fields Jr. has rushed for 614 yards in 9 games. Wide receiver Gavin Freeman leads with 46 receptions and 435 receiving yards.

Strong Cyclones Look to Continue Winning Ways

The Iowa State Cyclones play in the Big 12 conference and have enjoyed a positive season with a 7-4 record. They have been solid both at home and on the road, with a 5-2 home record and 2-2 on the road. Rocco Becht leads the team as the top quarterback, passing for 2,471 yards and 15 touchdowns in 11 games.

On the ground, Carson Hansen is the leading rusher for Iowa State with 841 yards and 6 touchdowns in 10 games. Abu Sama III adds depth to the backfield with 645 rushing yards. Brett Eskildsen tops the receiving charts for the team with 29 receptions and 507 yards, making him a key target.

Iowa State’s defense has been effective, allowing 229 points, which ranks them 77th. They have recorded 11 sacks and 10 interceptions, placing them among the top teams for turnovers. Despite some injury challenges, the Cyclones remain favorites, coming off a solid 38-14 win over Kansas.

Final Betting Pick

Iowa State is favored at -609 on the money line. They have a strong record after wins, going 14-3 in their last 17 games. This shows they know how to keep momentum. On the road, they have a balanced 2-2 record this season, which supports their ability to play well away from home.

The over/under is set at 47.5, and the prediction is for the total to go under. Both teams have had lower scoring games recently. Oklahoma State’s defense has been effective, holding opponents to fewer points. This makes the under a reasonable choice for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.