Louisville Cardinals vs SMU Mustangs NCAAF Betting Prediction
PublishedNovember 18, 2025,            Posted By: Maria Uebelhor
Last updated:November 18, 2025 ,

NCAAF Louisville Cardinals vs SMU Mustangs Prediction 11/22

On Saturday, November 22, 2025, the Louisville Cardinals will play against the SMU Mustangs in Week 13 of the regular season. The game will take place at Gerald J. Ford Stadium in Dallas, TX, with kickoff set for 12:00 PM. Fans can catch the action on ESPN2 as both teams enter the game with a 7-3 record.

Louisville vs. SMU Betting Prediction

  • Money Line Prediction: Louisville Cardinals +125. Louisville is undefeated on the road this season with a 3-0 record. They have shown strong performance away from home, making them a good value pick.
  • Over/Under Prediction: Over 52.5. Both teams have offenses that can put up points, with SMU scoring 322 points and Louisville scoring 315 points this season. This suggests the game could exceed the total line.

Team Trends

  • Louisville Cardinals are unbeaten on the road this season with a 3-0 record.
  • SMU Mustangs have a strong home record this season, winning 4 out of 5 games.
  • Louisville Cardinals’ defense ranks 16th in sacks with 20 this season.
  • SMU Mustangs’ offense ranks 20th in passing yards with 2,845 yards this season.
  • Both teams have identical overall records this season, standing at 7-3.

Louisville vs SMU Preview

The Louisville Cardinals and SMU Mustangs are set to meet in an important game for both teams. Each team holds a 7-3 record, but their recent performances differ. Louisville has struggled with a two-game losing streak, while SMU is on a two-game win streak. This game could be pivotal for their standings in the Atlantic Coast Conference.

Louisville has been strong on the road, winning all three away games this season. SMU, on the other hand, has been tough to beat at home, with a 4-1 record. The Mustangs are ranked third in their conference, while the Cardinals sit at seventh. Both teams will aim to improve their position with a win in this game.

SMU Mustangs Overview

The SMU Mustangs play in the Atlantic Coast Conference. Their home games are held at the Gerald J. Ford Stadium. This season, they have a record of 7-3, with a strong 4-1 record at home.

Kevin Jennings leads the team as the top quarterback with 2,810 passing yards and 21 touchdowns in 10 games. TJ Harden is the key running back, with 612 rushing yards and six touchdowns. On the receiving end, Jordan Hudson stands out with 595 yards and four touchdowns.

Offensively, SMU has scored 322 points, ranking 35th this season. Defensively, they have allowed 204 points and have achieved 33 sacks. The team is coming off a solid win of 45-13 over Boston College.

Louisville Cardinals Road Warriors

The Louisville Cardinals are part of the Atlantic Coast Conference. They play their home games at the L&N Federal Credit Union Stadium. This season, their overall record is 7-3, with a perfect 3-0 on the road.

Miller Moss is the leading quarterback for Louisville. He has thrown for 2,344 yards and 11 touchdowns in 10 games. Running back Isaac Brown has gained 782 rushing yards with five touchdowns in eight games.

Louisville has scored 315 points this season, placing them 38th in scoring. They have allowed 215 points and recorded 20 sacks. The Cardinals lost their last game to Clemson by a score of 20-19.

Final Betting Pick

Louisville has been strong on the road this season, with a perfect 3-0 record. This makes them a good pick for the money line at +125. They have shown they can handle pressure away from home, winning close games against teams like Miami and Virginia Tech.

For the over/under, both Louisville and SMU have offenses that can score. Louisville has scored 315 points, while SMU has 322 points this season. With both teams having high-scoring games, the total of 52.5 seems reachable.

 

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.