The Northwestern Wildcats will take on the USC Trojans in Week 11 of the 2025 season. The game will be held at the Los Angeles Memorial Coliseum on Friday, November 7, 2025, at 9:00 PM. Fans can watch the game on FOX.

Northwestern vs. USC Betting Prediction

• Money Line Prediction: USC Trojans -612. USC has a strong home record of 4-0 this season. They have shown consistency in winning at home.
• Over/Under Prediction: Over 50.5. USC games have often gone over this total, especially at home where they have a trend of high-scoring games.

Team Trends

• USC Trojans hold a perfect home record of 4-0 this season.
• Northwestern Wildcats have a road record of 1-2 this season.
• USC Trojans are ranked #20 in the AP Poll and #21 in the Coaches Poll.
• Northwestern Wildcats rank 42nd in rushing yards with 1,522 yards this season.
• USC Trojans have scored 318 points, ranking 16th in points for this season.

Northwestern vs USC Preview

The Northwestern Wildcats are set to challenge the USC Trojans in Week 11 of the 2025 season. The game will take place at the Los Angeles Memorial Coliseum. Northwestern comes into this game with a 5-3 record. They have been strong at home but have struggled on the road with a 1-2 record. Their conference record stands at 3-2, and they are currently on a one-game losing streak.

USC holds a 6-2 record and is ranked 20th in the AP Poll. They have been perfect at home this season with a 4-0 record. Their conference record is 4-1, and they are on a one-game win streak. The Trojans are ranked 6th in the conference, while Northwestern is ranked 9th. Fans can catch the game on FOX at 9:00 PM.

USC Trojans: A Strong Home Presence

The USC Trojans hold a record of 6-2 this season. Playing at the Los Angeles Memorial Coliseum, they are undefeated at home with a 4-0 record. Their conference record stands at 4-1, reflecting their strong performance in the Big Ten.

Quarterback Jayden Maiava leads the team with 2,315 passing yards. He ranks first in the team for both passing yards and touchdowns, contributing 15 to the team’s total. Running back Waymond Jordan has rushed for 576 yards, although his status is doubtful due to an ankle injury.

Wide receiver Makai Lemon has made 50 receptions, amassing 776 receiving yards. He also leads the team with six receiving touchdowns. Kicker Ryon Sayeri has been reliable, making 14 field goals and scoring 76 fantasy points, ranking him first on the team.

Northwestern Wildcats: Road Challenges Ahead

The Northwestern Wildcats have a 5-3 record this season. They play in the Big Ten conference. Their road record is 1-2, which shows they have some challenges away from home.

Preston Stone leads the team as quarterback, with 1,372 passing yards. He has thrown 10 touchdowns and 9 interceptions. Caleb Komolafe is the top running back, rushing for 608 yards and scoring 7 touchdowns.

The Wildcats have scored 180 points this season, ranking 83rd. On defense, they have allowed 134 points, placing them at 56th. Their defense has also recorded 12 sacks and 5 interceptions.

Final Betting Pick

The USC Trojans have a strong home record, winning all four home games this season. This makes the money line prediction for USC at -612 a solid choice. USC’s offense has been effective at home, scoring high in several games. Their ability to score and maintain leads at home gives them an edge against Northwestern.

For the over/under prediction, the total is set at 50.5. USC games have often gone over this total, especially at home. Their offense ranks 16th in points for this season, showing they can put up points. Northwestern’s defense has been solid, but USC’s home scoring trend supports the over bet.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.