The Arizona Cardinals will take on the Indianapolis Colts in Week 6 of the 2025 NFL season. The game is set for Sunday, October 12, 2025, at 1:00 PM. Fans can catch the action at Lucas Oil Stadium in Indianapolis, IN, with coverage on FOX. The weather forecast predicts a cool day with clear skies, but the retractable roof means the wind won’t affect the game.

Cardinals vs. Colts Betting Prediction

• Money Line Prediction: Indianapolis Colts -311. The Colts have a strong home record at 3-0 this season, making them a solid choice.
• Over/Under Prediction: Over 47.5 (-108). Both teams have shown the ability to score, with the Colts scoring 40 points in their last home game.

Team Trends

• The Indianapolis Colts have a perfect home record this season, winning all three games at Lucas Oil Stadium.
• Arizona Cardinals have an even road record this season, with one win and one loss away from home.
• The Colts’ head coach is Shane Steichen, while the Cardinals are led by Jonathan Gannon.
• In their last home game, the Colts defeated the Las Vegas Raiders 40-6.
• The Cardinals lost their last game against the Tennessee Titans by a score of 22-21.

Cardinals vs Colts Preview

The Arizona Cardinals will visit the Indianapolis Colts in Week 6 of the 2025 NFL season. The Colts are leading the AFC South with a 4-1 record, while the Cardinals are at the bottom of the NFC West with a 2-3 record. Both teams will look to their quarterbacks, Kyler Murray for the Cardinals and Daniel Jones for the Colts, who are projected to have similar passing yards and touchdowns in this game.

Running back Jonathan Taylor is expected to be a key player for the Colts, with projections of 97.1 rushing yards and 0.8 touchdowns. The Cardinals will rely on Michael Carter, who is projected to gain 45.8 rushing yards. The game will take place at Lucas Oil Stadium, where weather conditions will not be a factor due to the retractable roof. Fans can watch the game on FOX at 1:00 PM on Sunday, October 12, 2025.

Indianapolis Colts: Home Field Insights

The Indianapolis Colts are led by head coach Shane Steichen. They play in the AFC South and have a strong home record this season. At Lucas Oil Stadium, they are undefeated with a 3-0-0 record.

Quarterback Daniel Jones is a key player for the Colts. He is projected to score 17.5 fantasy points in this game. He has 1,290 passing yards this season, ranking third in the league.

Running back Jonathan Taylor is another top performer. He has 480 rushing yards, placing him first in the league. Taylor is projected to gain 97.1 rushing yards in the upcoming game.

Arizona Cardinals: Road Challenges Ahead

Kyler Murray leads the Arizona Cardinals under head coach Jonathan Gannon. Murray has thrown for 962 passing yards in five games this season, placing him first on the team. He is projected to earn 17.8 fantasy points in the upcoming game with 215.7 passing yards and 1.4 touchdowns.

Running back Michael Carter is expected to step up due to injuries. Carter has 52 rushing yards this season and is projected to gain 45.8 rushing yards in this game. Injuries have impacted the team, with James Conner and Trey Benson both out.

The Cardinals have a 2-3-0 record this season. Their road record stands at 1-1-0. The team hopes to improve this against the Colts at Lucas Oil Stadium.

Final Betting Pick

The Colts are a strong choice for the money line at -311. They have a perfect 3-0 home record this season. Their recent 40-6 win against the Raiders at home shows they can dominate opponents at Lucas Oil Stadium.

The over 47.5 points is a good pick. The Colts scored 40 points in their last home game. Both teams have shown they can score, with the Cardinals having scored over 20 points in three of their last five games.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.