Buffalo Bills vs Denver Broncos NFL Betting Prediction
PublishedJanuary 14, 2026,            Posted By: Maria Uebelhor
Last updated:January 14, 2026 ,

NFL Buffalo Bills vs Denver Broncos Prediction 1/17

The Buffalo Bills are set to play against the Denver Broncos in the 2025 Divisional Playoffs. This game will take place on Saturday, January 17, 2026, at 4:30 PM at Empower Field at Mile High in Denver, Colorado. The weather is expected to be very cold with clear skies, and fans can watch the game on CBS.

Bills vs. Broncos Betting Prediction

  • Money Line Prediction: Denver Broncos -110. The Broncos have a strong home record of 8-1 this season. Their defense ranks third in opponent score, making them a solid choice at home.
  • Over/Under Prediction: Under 46.5 (-114). Both teams have strong defenses, with the Broncos ranked third in opponent score and the Bills ranked 11th. This suggests a lower-scoring game.

Team Trends

  • The Denver Broncos have a strong home record this season with 8 wins and only 1 loss.
  • Buffalo Bills have won their only postseason game on the road this season.
  • In their last game, the Buffalo Bills won against the New York Jets with a score of 35-8.
  • Denver Broncos recently defeated the Los Angeles Chargers 19-3 at home.
  • The game will be played at Empower Field at Mile High, where the weather is expected to be very cold but with clear skies.

Bills vs Broncos Preview

The Buffalo Bills are gearing up to meet the Denver Broncos in the 2025 Divisional Playoffs. The Bills finished the regular season with a 12-5 record, ranking second in the AFC East. They recently overcame the Jacksonville Jaguars in a close Wild Card game, winning 27-24. Quarterback Josh Allen is expected to lead the team with a projected 265.8 passing yards and 1.6 touchdowns.

The Denver Broncos, leading the AFC West with a 14-3 record, will host the game at Empower Field at Mile High. The Broncos have a strong home record of 8-1, and quarterback Bo Nix is projected to throw for 231.2 yards and 1.5 touchdowns. The game promises to be a test of skill and strategy as both teams aim for a spot in the next playoff round.

Denver Broncos: A Look at the Home Team

The Denver Broncos are ready to play at Empower Field at Mile High. They finished the season with a strong 14-3 record. Sean Payton is the head coach, leading the team to success in the AFC West.

Quarterback Bo Nix is a key player for the Broncos. He has 3931 passing yards and 25 touchdowns this season. RJ Harvey is another important player, with 540 rushing yards and 7 touchdowns.

The Broncos have a strong offense and defense. Their offense ranks 10th in scoring with 425 points. On defense, they rank 3rd, allowing only 311 opponent points.

Buffalo Bills: Ready for the Road Challenge

The Buffalo Bills are set to visit the Denver Broncos with a solid record. Under head coach Sean McDermott, they finished the regular season at 12-5. The Bills excelled on the road, winning 5 of 8 games.

Quarterback Josh Allen leads the team’s offense. He has 3668 passing yards and 25 touchdowns from the regular season. For this game, he is projected to throw for 265.8 yards and 1.6 touchdowns.

Running back James Cook is a vital part of the Bills’ ground game. He rushed for 1621 yards and 12 touchdowns during the regular season. Cook is expected to add 92.1 rushing yards and 0.7 touchdowns in this game.

Final Betting Pick

The Denver Broncos are a strong pick on the money line at -110. They have an impressive home record of 8-1 this season. Their defense is ranked third in opponent score, which makes them tough to beat at home. For the over/under, the under 46.5 at -114 is a good choice. Both teams have strong defenses, with the Broncos ranked third and the Bills ranked 11th in opponent score. This suggests the game might have fewer points scored.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.