The San Francisco 49ers travel to face the Tampa Bay Buccaneers in Week 6 of the 2025 NFL season. The game is set for Sunday, October 12, 2025, at 4:25 PM at Raymond James Stadium in Tampa Bay, FL. The weather forecast predicts a warm day with a clear sky and a light breeze. Fans can catch the action on CBS.

49ers vs. Buccaneers Betting Prediction

• Money Line Prediction: San Francisco 49ers +134. The 49ers have a strong road record this season at 3-0-0. This makes them a good value bet against the Buccaneers.
• Over/Under Prediction: Over 47.5 (-109). Both teams have shown the ability to score, with the Buccaneers having a high-scoring offense ranked 4th last season.

Team Trends

• The San Francisco 49ers have a perfect road record this season with 3 wins and 0 losses.
• Tampa Bay Buccaneers have a home record of 1 win and 1 loss this season.
• Both the San Francisco 49ers and Tampa Bay Buccaneers have an overall season record of 4 wins and 1 loss.
• The game will be played at Raymond James Stadium in Tampa Bay, Florida, with clear skies expected.
• Baker Mayfield, the Buccaneers’ quarterback, threw for 379 yards and 2 touchdowns in their recent win against the Seattle Seahawks.

49ers vs Buccaneers Preview

The San Francisco 49ers, sitting at the top of the NFC West with a 4-1 record, are set to play against the Tampa Bay Buccaneers, who also hold a 4-1 record and lead the NFC South. Both teams are looking strong this season, making this game crucial for maintaining their standings. The 49ers have been impressive on the road, winning all three of their away games so far.

Brock Purdy, the 49ers’ quarterback, is expected to lead his team with 275.1 passing yards and 1.7 touchdowns. On the other side, Buccaneers’ quarterback Baker Mayfield is projected to throw for 233.3 yards and 2 touchdowns. With both teams having strong offenses and solid records, fans can expect a competitive game at Raymond James Stadium.

Spotlight on Tampa Bay Buccaneers

The Tampa Bay Buccaneers are off to a strong start with a 4-1 record. They play in the NFC South and have been solid at home with a 1-1 record. Head Coach Todd Bowles leads the team at Raymond James Stadium.

Baker Mayfield is the starting quarterback for the Buccaneers. He is projected to earn 18.2 fantasy points this game with 233.3 passing yards and 2 touchdowns. On the ground, Rachaad White is expected to contribute with 49.1 rushing yards and 0.4 touchdowns.

In the receiving corps, Emeka Egbuka stands out with a projection of 11.1 fantasy points. He is predicted to gain 70.0 receiving yards and 0.7 touchdowns. The Buccaneers’ defense ranks well, finishing last season with 46 sacks, placing them 5th in the league.

San Francisco 49ers: Road Warriors in Action

The San Francisco 49ers are also 4-1 this season. They play in the NFC West and have been perfect on the road with a 3-0 record. Head Coach Kyle Shanahan leads the team at Levi’s Stadium.

Brock Purdy is the starting quarterback for the 49ers and is projected to earn 18.5 fantasy points. He is expected to throw for 275.1 yards and 1.7 touchdowns. Christian McCaffrey leads the ground game with 64.2 rushing yards and 0.5 touchdowns expected.

In the receiving group, Ricky Pearsall is a key player with a projection of 8.2 fantasy points. He is anticipated to collect 62.6 receiving yards and 0.3 touchdowns. The 49ers’ defense recorded 37 sacks last season, ranking 12th in the league.

Final Betting Pick

The San Francisco 49ers are a solid pick for the money line at +134. They have a perfect 3-0 record on the road this season. Brock Purdy is expected to have a strong game with 275.1 passing yards and 1.7 touchdowns, which could help them secure a win.

For the over/under, betting over 47.5 points is a good choice. The Buccaneers have a high-scoring offense, ranked 4th last season. Both teams have shown they can put up points, making it likely the total will exceed 47.5 points.

Why bet with the big guys from out of state when you can bet local? Action 24/7 Online Sportsbook is proud to be Tennessee-owned and operated, bringing Volunteer State fans the best in sports betting. Real people, real payouts, and real Tennessee pride. When you bet local, everybody wins.

---

All odds are courtesy of Action247 Sportsbook. Good luck!!

---

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.