The Jacksonville Jaguars will travel to face the Indianapolis Colts at Lucas Oil Stadium on Sunday, December 28, 2025. The game is set for 1:00 PM and will be broadcast on FOX. Both teams are part of the AFC South Division, and this game is a key matchup in Week 17 of the 2025 season.

Jaguars vs. Colts Betting Prediction

• Money Line Prediction: Jacksonville Jaguars -290. The Jaguars have a strong road record of 5-2 this season. They also won their last game against the Colts, making them a solid choice.
• Over/Under Prediction: Over 48.5. Recent games for both teams have seen high scores, with the Jaguars scoring over 30 points in their last three games.

Team Trends

• The Jacksonville Jaguars have an 11-4-0 record this season.
• The Indianapolis Colts have a strong home record of 6-2-0.
• Trevor Lawrence threw for 279 yards and 3 touchdowns in the Jaguars’ recent win over the Denver Broncos.
• The Colts lost to the 49ers 48-27 in their last home game.
• The Jaguars defeated the Colts 36-19 in their previous meeting this season.

Jaguars vs Colts Preview

The Jacksonville Jaguars and Indianapolis Colts are set to play at Lucas Oil Stadium. The Jaguars lead the AFC South with an 11-4 record. They are on a six-game winning streak. The Colts are third in the division with an 8-7 record, but they have lost their last five games.

Trevor Lawrence is expected to lead the Jaguars with 242.6 passing yards and 1.7 touchdowns. Travis Etienne Jr. could add 61.6 rushing yards. For the Colts, Jonathan Taylor might gain 91.1 rushing yards with 0.9 touchdowns. Philip Rivers is projected for 208.6 passing yards. The game will be on FOX at 1:00 PM.

Indianapolis Colts: Home Field Advantage

The Indianapolis Colts are set to play at Lucas Oil Stadium. They have a solid home record of 6-2 this season. Shane Steichen leads the team as head coach.

Quarterback Philip Rivers is expected to throw for 208.6 yards and 1.4 touchdowns in the game. Jonathan Taylor is projected to rush for 91.1 yards and score 0.9 touchdowns. Alec Pierce might lead the receiving corps with 60.9 yards and 0.5 touchdowns.

On defense, the Colts have recorded 36 sacks, ranking 13th in the league. They have also recovered 10 fumbles, placing them 5th. The team’s defense is crucial in turning the tide during games, despite ranking 29th in opponent offensive yards.

Jacksonville Jaguars: Road Warriors

The Jacksonville Jaguars are ready to play against the Colts. Head coach Liam Coen has guided the team to an 11-4 record this season. Their road record stands at 5-2, showing strong performance away from home.

Quarterback Trevor Lawrence is expected to pass for 242.6 yards and 1.7 touchdowns. Running back Travis Etienne Jr. may rush for 61.6 yards and score 0.5 touchdowns. Parker Washington might lead the receivers with 52.9 yards and 0.4 touchdowns.

The Jaguars have recorded 34 sacks, placing them 15th in the league. They have also made 6 interceptions and recovered 3 fumbles. Despite some injuries, the defense remains focused on improving their rank in opponent yards allowed.

Final Betting Pick

The Jaguars are a strong pick for the money line due to their solid road performance. They have a 5-2 road record this season. Trevor Lawrence is projected to have a good game with 242.6 passing yards and 1.7 touchdowns. The Jaguars’ recent win against the Colts adds confidence to this choice.

The over 48.5 prediction is supported by the Jaguars’ recent scoring trends. They have scored over 30 points in their last three games. Both teams have shown the ability to score, as seen in their recent high-scoring games. This makes the over a reasonable prediction for this matchup.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.