The New Orleans Saints will play against the Buffalo Bills on Sunday, September 28, 2025. The game will be held at Highmark Stadium in Orchard Park, NY. Fans can watch the action on CBS at 1:00 PM.

Saints vs. Bills Betting Prediction

• Money Line Prediction: Buffalo Bills -1708. The Bills have a strong home record of 2-0 this season. They are facing a Saints team that has struggled on the road and has not won a game this season.
• Over/Under Prediction: Under 47.5 (-105). The Saints have not scored more than 21 points in any game this season. The Bills’ defense ranks well, which could limit the Saints’ scoring opportunities.

Team Trends

• The Buffalo Bills have a perfect 3-0-0 record this season.
• The New Orleans Saints have yet to win a game this season, standing at 0-3-0.
• Buffalo Bills have won both of their home games this season.
• New Orleans Saints lost their only road game this season against the Seattle Seahawks, 44-13.
• The game will take place at Highmark Stadium, home of the Buffalo Bills.

Saints vs Bills Preview

The New Orleans Saints are looking to secure their first win of the 2025 season as they visit the Buffalo Bills. The Saints are currently 0-3 and sit at the bottom of the NFC South. Quarterback Spencer Rattler will lead the Saints with a projected 196.9 passing yards and 1.2 touchdowns. Running back Alvin Kamara is expected to contribute with 59.6 rushing yards and 3.3 receptions.

The Buffalo Bills are off to a strong start with a 3-0 record, leading the AFC East. Quarterback Josh Allen is projected to add 239 passing yards and 1.7 touchdowns to his season totals. Running back James Cook is expected to rush for 74.9 yards and score 0.8 touchdowns. The Bills aim to continue their winning streak at home in Highmark Stadium.

Buffalo Bills: Current Season Overview

The Buffalo Bills are having a strong start to their season with a perfect 3-0 record. They have been unbeatable at home with two wins and have one win on the road. In division games, they have secured two victories.

Josh Allen leads the team as the starting quarterback. In the first three games, he has thrown for 755 yards and five touchdowns. He stands first in the league for both passing yards and touchdowns.

Sean McDermott is the head coach of the Bills. Under his leadership, the team is excelling in both offense and defense. The Bills play their home games at Highmark Stadium in the AFC East division.

New Orleans Saints: Aiming for a Turnaround

The New Orleans Saints are looking to improve their season after a challenging start. They have a record of 0-3, with two losses at home and one on the road. Head coach Kellen Moore guides the team, leading them in the NFC South division.

Spencer Rattler is the starting quarterback for the Saints. He has thrown for 639 yards and four touchdowns this season. In this upcoming game, he is projected to gain 196.9 passing yards and 1.2 touchdowns.

The Saints rely on Alvin Kamara at running back. Kamara has 186 rushing yards and one touchdown in three games. Chris Olave is the top wide receiver, with 165 receiving yards this season.

Final Betting Pick

The Buffalo Bills have a strong track record at home this season, winning both of their games. Their offense is ranked second from last season, and they have shown the ability to score high. Josh Allen is expected to lead with over 239 passing yards and nearly two touchdowns, providing a solid foundation for the Bills’ money line prediction.

The New Orleans Saints have struggled on the road, losing their only away game this season. Their offense has not scored more than 21 points in any game. With the Bills’ defense ranking 11th in opponent scoring, the under 47.5 prediction is supported by the Saints’ limited scoring potential. The Saints’ quarterback, Spencer Rattler, is projected to have under 200 passing yards, which may not be enough to challenge the Bills’ defense.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.