On Sunday, November 30, 2025, the San Francisco 49ers will visit the Cleveland Browns at Huntington Bank Field in Cleveland, Ohio. The game is set to kick off at 1:00 PM and will be broadcast on CBS. The 49ers have a record of 8-4, while the Browns stand at 3-8 this season. This outdoor game will be an important one for both teams as they progress through Week 13 of the 2025 NFL season.

49ers vs. Browns Betting Prediction

• Money Line Prediction: San Francisco 49ers -239. The 49ers have a strong road record at 5-2. They have been consistent in their recent games, winning three of their last four. The Browns have struggled at home with a 2-3 record this season.
• Over/Under Prediction: Under 38.0. Both teams have shown strong defensive capabilities. The 49ers have allowed fewer points in recent games, while the Browns’ offense ranks low in scoring.

Team Trends

• The San Francisco 49ers have a strong road record this season at 5-2.
• The Cleveland Browns have struggled at home, holding a 2-3 record this season.
• In their last game, the 49ers won against the Carolina Panthers with a score of 20-9.
• The Browns recently won against the Las Vegas Raiders with a score of 24-10.
• San Francisco 49ers’ head coach is Kyle Shanahan, while the Cleveland Browns’ head coach is Kevin Stefanski.

49ers vs Browns Preview

On Sunday, November 30, 2025, the San Francisco 49ers will travel to face the Cleveland Browns at Huntington Bank Field. The 49ers are having a strong season with an 8-4 record, sitting third in the NFC West. Meanwhile, the Browns are struggling, holding a 3-8 record and sitting at the bottom of the AFC North.

Brock Purdy leads the 49ers with a projection of 244.5 passing yards and 1.7 touchdowns. Christian McCaffrey is expected to contribute with 66.9 rushing yards and 5.6 receptions. For the Browns, Shedeur Sanders is projected to pass for 208 yards and 1.4 touchdowns. Quinshon Judkins is set to add 68 rushing yards. Both teams will aim to improve their standings as they compete in Week 13 of the NFL season.

Spotlight on the Cleveland Browns: Key Players and Stats

The Cleveland Browns have a challenging season with a 3-8 record. Head Coach Kevin Stefanski leads the team in the AFC North. The Browns play at Huntington Bank Field, where they hold a home record of 2-3.

Quarterback Shedeur Sanders is projected to gain 208 passing yards and 1.4 touchdowns this game. Quinshon Judkins is a standout running back with 68 rushing yards and 0.6 touchdowns projected. Jerry Jeudy leads the wide receivers, expected to gain 42.6 receiving yards.

Harold Fannin Jr. is the top tight end, with 42.7 receiving yards projected. Kicker Andre Szmyt is set to make 1.4 field goals and 1.9 extra points. Despite several injuries, including Deshaun Watson and others, the team remains focused on improving their season record.

San Francisco 49ers Game Plan: Key Players and Projections

Brock Purdy leads the San Francisco 49ers as the top quarterback. He is expected to pass for 244.5 yards and score 1.7 touchdowns. Christian McCaffrey, a key running back, is projected to rush for 66.9 yards and catch 5.6 passes.

Jauan Jennings is the leading wide receiver, expected to gain 45.7 receiving yards. George Kittle, the tight end, is projected to contribute 59.4 receiving yards and 0.4 touchdowns. Kicker Eddy Piñeiro aims to make 1.4 field goals, though he is listed as questionable.

Head Coach Kyle Shanahan guides the 49ers in the NFC West. The team has an 8-4 record, with a strong 5-2 performance on the road. Injuries, including Nick Bosa and Brandon Aiyuk, could impact their lineup for this game.

Final Betting Pick

The San Francisco 49ers are a strong choice for the money line at -239. They have a solid road record of 5-2 this season. In recent games, they have won three out of four, showing consistency. The 49ers’ offense is led by Brock Purdy, who is projected to throw for 244.5 yards and nearly two touchdowns. Christian McCaffrey adds to their strength with 66.9 rushing yards and 5.6 receptions per game.

The under 38.0 is a good pick due to both teams’ defensive strengths. The 49ers have allowed fewer points recently, and their defense ranks well in interceptions and fumbles recovered. The Browns’ offense ranks low in scoring, with a season rank of 30th. Their home record is 2-3, which shows struggles in their own stadium. This combination of factors points to a low-scoring game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.