Tennessee Titans vs Indianapolis Colts NFL Betting Prediction
PublishedOctober 22, 2025,            Posted By: Maria Uebelhor
Last updated:October 22, 2025 ,

NFL Tennessee Titans vs Indianapolis Colts Prediction 10/26

The Tennessee Titans will take on the Indianapolis Colts at Lucas Oil Stadium on Sunday, October 26, 2025, at 4:25 PM. The game will be on CBS. The Colts have a strong record of 6-1, while the Titans are looking to improve from their 1-6 start. The weather is expected to be mild with overcast clouds, but the retractable roof should keep conditions stable.

Titans vs. Colts Betting Prediction

  • Money Line Prediction: Indianapolis Colts -1203. The Colts have a strong home record of 4-0 and have been performing well this season with a 6-1 record. The Titans have struggled, especially on the road with a 1-3 record.
  • Over/Under Prediction: Under 47.0 (-109). The Titans have been struggling offensively, and the Colts’ defense has been effective in limiting opponents’ scores.

Team Trends

  • The Indianapolis Colts have a strong home record this season, with 4 wins and no losses.
  • The Tennessee Titans have struggled on the road, with a record of 1 win and 3 losses.
  • In their last game, the Colts won against the Los Angeles Chargers with a score of 38-24.
  • The Titans lost their most recent game at home to the New England Patriots, 31-13.
  • Both teams play in the AFC South division.

Titans vs Colts Preview

The Tennessee Titans will travel to Lucas Oil Stadium to face the Indianapolis Colts in Week 8 of the 2025 NFL season. The Colts are leading the AFC South with a 6-1 record and aim to continue their winning streak. The Titans, on the other hand, are at the bottom of the division with a 1-6 record, hoping to turn their season around.

Key players to watch include Titans’ quarterback Cameron Ward, who is projected to throw for 195.6 yards and 1.3 touchdowns. The Colts’ Daniel Jones is expected to pass for 239.8 yards and 1.7 touchdowns. Colts’ running back Jonathan Taylor could have a big game, with projections of 102 rushing yards and a touchdown. The Titans will rely on Tony Pollard, who is projected to gain 43.9 rushing yards. Both teams will look to execute their game plans effectively under the retractable roof, keeping weather conditions from affecting play.

Colts Gearing Up for Action

The Indianapolis Colts are having a great season with a 6-1-0 record. They have not lost at home this year, going 4-0-0 at Lucas Oil Stadium. Head Coach Shane Steichen is leading the team well in the AFC South division.

Daniel Jones is the top quarterback for the Colts this game. He is expected to throw for about 239.8 yards and get 1.7 touchdowns. Running back Jonathan Taylor is also set to make an impact with 102.0 rushing yards and 1 touchdown.

The Colts’ offense has scored 377 points this season, ranking 16th. Their defense has recorded 36 sacks, placing them 13th in that category. However, they have some injury concerns, with key players like Anthony Richardson Sr. and Spencer Shrader on injured reserve.

Titans Look to Turn Season Around

The Tennessee Titans are led by interim head coach Mike McCoy. They hold a 1-6-0 record and are 1-3-0 on the road. Cameron Ward is their top quarterback, with projections of 195.6 passing yards and 1.3 touchdowns.

Running back Tony Pollard is expected to gain 43.9 rushing yards this game. He has scored 2 rushing touchdowns this season. Wide receiver Calvin Ridley is another key player, although he’s listed as questionable with a hamstring injury.

The Titans’ offense ranked 25th last season, scoring 311 points. Their defense recorded 32 sacks, placing them 16th. The team faces injury challenges with several players on the injured reserve list.

Final Betting Pick

The Colts have a strong home record, winning all four games at Lucas Oil Stadium. This adds confidence to the money line prediction for the Colts at -1203. Daniel Jones leads the offense with nearly 240 passing yards per game, while Jonathan Taylor is expected to rush for over 100 yards. The Colts’ defense has been solid, making it tough for opponents to score.

The Titans have struggled on the road, with a 1-3 record. Their offense has not been performing well, with Cameron Ward projected to pass for under 200 yards. The Titans’ recent games show low scoring, which supports the under 47.0 prediction. The Colts’ defense can limit the Titans’ scoring, making the under bet a good choice.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.