The Louisville Cardinals, ranked #6, will take on the #22 Indiana Hoosiers on Saturday, December 6, 2025, at 2:15 PM ET. This non-conference game will be held at Gainbridge Fieldhouse in Indianapolis, IN, and will be broadcast on CBS. Louisville is favored with a spread of -4.5, while Indiana comes in as the underdog with a spread of +4.5.

Louisville vs. Indiana Betting Prediction

• Spread Prediction: Indiana +4.5. Indiana has a strong home record and is ranked #22. They have a good chance to cover the spread against Louisville.
• Over/Under Prediction: Under 162.5. Both teams have shown trends of hitting the under in recent games, making this a safer bet.

Team Trends

• The game between Louisville Cardinals and Indiana Hoosiers will be held at Gainbridge Fieldhouse, a neutral site in Indianapolis.
• Louisville Cardinals are favored with a spread of -4.5, while Indiana Hoosiers have a spread of +4.5.
• Louisville Cardinals have a strong straight-up record of 7-1 in all games this season.
• Indiana Hoosiers also hold a 7-1 straight-up record in all games this season.
• The over/under for the game is set at 162.5 points.

Louisville vs Indiana Preview

The Louisville Cardinals are set to play against the Indiana Hoosiers on Saturday, December 6, 2025. The game will take place at Gainbridge Fieldhouse in Indianapolis, a neutral site. Louisville, ranked #6, holds a 7-1 record this season, with a recent loss to Arkansas. Despite this setback, they have been strong at home, winning all six games there.

Indiana, ranked #22, also has a 7-1 record. They recently lost to Minnesota but have been perfect at home with a 7-0 record. This game will be a test for both teams, as they face each other on neutral ground. The Cardinals are the favorites, with a spread of -4.5, while the Hoosiers enter as the underdogs with a spread of +4.5.

Indiana Hoosiers: A Strong Home Record

The Indiana Hoosiers have had a solid start to the 2026 season with a 7-1 record. Their performance at home has been perfect, winning all seven games. However, they faced a setback in their only away game against Minnesota. The Hoosiers are known for their offensive skills, scoring an average of 86.4 points per game. Their shooting accuracy is notable, with a field goal percentage of 49.2%. They also make an average of 10.2 three-pointers per game, ranking them 46th in the nation. Key players like Tucker DeVries and Tayton Conerway have been instrumental in the team’s success. DeVries averages 16.8 points per game, while Conerway contributes 12.6 points on average. Their teamwork is evident in the Hoosiers’ high assist numbers, averaging 20 assists per game.

Louisville Cardinals: High-Octane Offense

The Louisville Cardinals have been impressive this season, holding a 7-1 record. They are ranked 6th in the nation, showing their strength in the Atlantic Coast Conference. Their only loss came against Arkansas, where they scored 80 points. Offensively, the Cardinals score an average of 94.6 points per game, placing them 9th in the nation. They make 12.6 three-pointers per game, ranking 3rd. Players like Ryan Conwell and Mikel Brown Jr. lead the charge, with Conwell averaging 19.5 points per game. On defense, the Cardinals average 8.5 steals per game. They also grab 44.8 rebounds per game, which ranks them 8th nationally. Key players include Sananda Fru, who contributes with both scoring and rebounding.

Final Betting Pick

Indiana’s strong home record makes the +4.5 spread a good pick. They are ranked #22 and have won all their home games this season. Playing at a neutral site in Indianapolis could feel like a home game for them, giving them an edge.

The under 162.5 is also a solid choice. Both teams have been hitting the under in recent games. Indiana’s slower pace of 68.4 possessions per game could help keep the score lower.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.