The Indiana State Sycamores will take on the #4 Duke Blue Devils on Friday, November 14, 2025, at 7:00 PM ET. This non-conference game will be held at Cameron Indoor Stadium in Durham, NC. Fans can catch the game on ACCN as the Sycamores from the Missouri Valley Conference face the Blue Devils from the Atlantic Coast Conference.

Indiana State vs. Duke Betting Prediction

• Spread Prediction: Indiana State +37.5. Indiana State has a decent record, and Duke may not cover such a large spread despite their strong start.
• Over/Under Prediction: Under 162.5. Duke’s games have hit the under in two of their last three games, suggesting this total may be too high.

Team Trends

• The game is at Cameron Indoor Stadium in Durham, NC.
• Indiana State Sycamores are part of the Missouri Valley Conference.
• Duke Blue Devils are ranked #4 and belong to the Atlantic Coast Conference.
• The spread for Indiana State is +37.5, while Duke’s spread is -37.5.
• The game will be broadcast on ACCN.

Indiana State vs Duke Preview

The Indiana State Sycamores will meet the Duke Blue Devils on Friday night at Cameron Indoor Stadium. The Sycamores have had a solid start to their season with a 2-1 record. They recently secured a 64-55 win against the SIUE Cougars, showing strong defense.

Duke, ranked #4, has been dominant with a 3-0 record. They crushed the Army Black Knights 114-59 in their latest game. Duke’s offense has been impressive, and they will look to continue their winning streak at home.

Duke Blue Devils: Dominant Start to the Season

The Duke Blue Devils are off to a strong start this season. They hold a 3-0 record, with two wins on the road and one at home. Their recent victory against Army was by a margin of 55 points. In their last game against Western Carolina, Duke won by 41 points. Cameron Boozer stood out with 25 points and 8 rebounds. The team showed solid shooting with a field goal percentage of 46.9%. Duke’s offensive stats are impressive. They score an average of 94.7 points per game. Their three-point shooting is effective, with 11.7 made per game at a 38% success rate.

Indiana State Sycamores: Aiming for an Upset

The Indiana State Sycamores enter the game with a 2-1 record. They have shown strength in their offense, scoring an average of 81.3 points per game. Their field goal percentage sits at 46.7%, which ranks them 162nd in the nation. In recent games, the Sycamores displayed their scoring ability with a 104-73 win over Illinois Tech. Key players like Ian Scott have been significant contributors. Scott averages 14.3 points and 10 rebounds per game, making him a player to watch. The Sycamores have struggled with three-point shooting, hitting only 25.6% from beyond the arc. However, their two-point shooting is more reliable, with a 62.3% success rate. On defense, they average 7.7 steals per game, which could help them against Duke’s strong offense.

Final Betting Pick

Indiana State’s spread of +37.5 looks appealing given their decent start to the season. They have a 2-1 record and show strong offensive stats with 81.3 points per game. While Duke is a top team, covering such a large spread can be difficult, even for them.

The over/under of 162.5 seems high when considering Duke’s recent games. Two of their last three games have gone under this total. Indiana State’s slower pace of 59 possessions per game might also contribute to a lower-scoring game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.