Louisville Cardinals vs Tennessee Volunteers NCAAB Betting Prediction
PublishedDecember 16, 2025,            Posted By: Maria Uebelhor
Last updated:December 16, 2025 ,

NCAAB Louisville Cardinals vs Tennessee Prediction 12/16

On Tuesday, December 16, 2025, the #11 Louisville Cardinals will play against the #20 Tennessee Volunteers The game is set to start at 7:00 PM ET at Thompson-Boling Arena at Food City Center in Knoxville, TN. This non-conference game will be shown on ESPN, with Tennessee favored by a spread of -1.5.

Louisville vs. Tennessee Betting Prediction

  • Spread Prediction: Louisville +1.5. Louisville has a strong record and has been successful against the spread, going 7-3. Tennessee has struggled recently with a 0-3 ATS record in their last three games.
  • Over/Under Prediction: Over 157.5. Louisville scores 94.3 points per game, which is high. Both teams have hit the Over in 60% of their games this season.

Team Trends

  • The game will take place at Thompson-Boling Arena at Food City Center in Knoxville, TN.
  • Louisville Cardinals have a strong straight-up record of 9-1 in their last 10 games.
  • Tennessee Volunteers are the favorites with a spread of -1.5.
  • Louisville Cardinals have gone 3-0 on the Over/Under in their last 3 games.
  • Tennessee Volunteers have struggled against the spread, going 0-3 in their last 3 games.

Louisville vs Tennessee Preview

The Louisville Cardinals head into Tuesday’s game with a strong 9-1 record this season. They recently secured a 99-73 win over the Memphis Tigers, showing their offensive strength. Key players like Ryan Conwell and Mikel Brown Jr. have been putting up solid numbers, contributing to their success. With a 2-1 record on the road, they aim to add another win away from home.

The Tennessee Volunteers, ranked #20, are looking to bounce back after a few tough games. They have a 7-3 record, with their last game ending in a 75-62 loss to Illinois. Despite recent setbacks, players like Ja’Kobi Gillespie and Jaylen Carey have shown potential on the court. With a 6-2 home record, Tennessee hopes to use their home-court advantage to secure a win against Louisville.

Volunteers Ready to Defend Home Court

The Tennessee Volunteers are ranked #20 in the nation. They play in the Southeastern Conference. Their current record is 7-3, with a strong 6-2 performance at home. In recent games, the Volunteers have faced tough opponents. They lost to Illinois by 13 points, Syracuse by 2 points, and Kansas by 5 points. Despite these losses, the Volunteers have shown they can compete. Key players for Tennessee include Ja’Kobi Gillespie and Nate Ament. Gillespie averages 17.3 points per game, while Ament scores 16.3 points per game. These players are crucial for the Volunteers’ success this season.

Cardinals Aim to Outscore Opponents

The Louisville Cardinals are ranked #11 in the nation. They have a strong 9-1 record this season. Their away record is 2-1, which shows they can win on the road. Louisville’s offense is powerful, scoring 94.3 points per game. They rank 7th in the nation in scoring. The team makes 13.2 three-pointers per game, ranking 3rd in this category. Key players for Louisville include Ryan Conwell and Mikel Brown Jr. Conwell averages 19.4 points per game, while Brown Jr. scores 16.6 points per game. These players will be important against Tennessee.

Final Betting Pick

Louisville’s strong record of 9-1 and their success against the spread make them a solid pick at +1.5. They have covered the spread in 7 out of 10 games. Tennessee, on the other hand, has struggled recently with a 0-3 ATS record in their last three games. This gives Louisville an edge in this matchup.

The Over 157.5 is a good choice given Louisville’s high scoring average of 94.3 points per game. Both teams have hit the Over in 60% of their games this season. Louisville’s fast pace with 72.1 possessions per game and Tennessee’s ability to score 80.9 points per game suggest a high-scoring game is likely.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.