The Memphis Tigers will take on the #11 Louisville Cardinals on Saturday, December 13, 2025, at 3:30 PM ET. This non-conference game will be held at the KFC Yum! Center in Louisville, KY. Fans can catch the action on ESPN as the Tigers, underdogs with a spread of +15.5, face the favored Cardinals, who hold a spread of -15.5.

Memphis vs. Louisville Betting Prediction

• Spread Prediction: Memphis +15.5. Memphis has been strong against the spread, going 7-1 overall and 4-0 as an underdog. This makes them a good choice to cover the spread.
• Over/Under Prediction: Under 161.5. Memphis games have gone under in 5 of their last 6, while Louisville’s games have been more balanced. The trends suggest the total will stay under.

Team Trends

• The game is set at the KFC Yum! Center in Louisville, KY, and will be broadcast on ESPN.
• Memphis Tigers are the underdog with a spread of +15.5, while Louisville Cardinals have a spread of -15.5.
• Memphis Tigers have a strong ATS record as underdogs, going 4-0 in their recent games.
• Louisville Cardinals have a solid SU record, winning 8 out of their last 9 games.
• The Over/Under for the game is set at 161.5, with the Under having slightly better odds.

Memphis vs Louisville Preview

The Memphis Tigers are set to visit the Louisville Cardinals this Saturday. The Tigers, with a 4-4 record, have shown strong performances at home but are still seeking their first away win. Recent victories over Baylor and New Orleans have boosted their confidence, with standout performances from players like Zach Davis and Dug McDaniel.

The Louisville Cardinals, ranked #11, hold an impressive 8-1 record. They have been dominant at home, winning all six games. The Cardinals recently defeated Indiana, showcasing their strong offense. Key players like Ryan Conwell and J’Vonne Hadley have been instrumental in their success. This game will be an exciting test for both teams.

Louisville Cardinals: Strong at Home

The Louisville Cardinals have had a strong start to the 2026 regular season. They hold an 8-1 record, with an impressive 6-0 at home. The team ranks 11th in the AP poll and competes in the Atlantic Coast Conference. In their recent games, the Cardinals secured a 87-78 win against Indiana Hoosiers. Ryan Conwell led the team with 21 points. Sananda Fru also contributed with 12 points and seven rebounds in that game. Louisville’s offensive stats are notable, with 93.8 points per game, ranking 9th. They also excel in three-point shooting, making 12.7 per game, which is 3rd in the nation. Their defense, however, could improve, as they average 8.6 steals per game.

Memphis Tigers: Seeking to Upset

The Memphis Tigers are part of the American Athletic Conference. They have a 4-4 record this season. On the road, they have struggled, losing their only away game so far. In recent games, Memphis showed strong performances at home. They secured a 78-71 win over Baylor Bears. Zach Davis was a key player, scoring 23 points and grabbing 13 rebounds. Offensively, the Tigers average 76 points per game. They attempt around 61 field goals each game. Their defense averages 8.4 steals per game, which ranks them 570th nationally.

Final Betting Pick

Memphis has been strong against the spread, especially as an underdog. Their 7-1 record against the spread shows they often perform better than expected. This makes them a solid pick to cover the +15.5 spread against Louisville.

The over/under is set at 161.5, and Memphis games have stayed under in 5 of their last 6. Louisville scores a lot, but Memphis’ lower-scoring games suggest the total will stay under. This trend makes the under a good choice for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.