The Duke Blue Devils are set to play against the Clemson Tigers on Saturday, November 1, 2025. This game is part of Week 10 of the 2025 regular season. It will take place at Memorial Stadium in Clemson, SC, with a kickoff time of 12:00 PM. Fans can catch the action on ACCN. Both teams are part of the Atlantic Coast Conference.

Duke vs. Clemson Betting Prediction

• Money Line Prediction: Duke Blue Devils +142. Duke has a strong road record this season at 2-1. Clemson struggles at home with a 1-3 record, making Duke a good value pick.
• Over/Under Prediction: Over 55.5. Duke’s last three games as an underdog have all gone over the total. Both teams have shown they can score, suggesting a high-scoring game.

Team Trends

• Duke Blue Devils have a road record of 2-1 this season.
• Clemson Tigers have a home record of 1-3 this season.
• The game will be played at Memorial Stadium in Clemson, SC.
• Duke Blue Devils rank 18th in passing yards this season with 2,233 yards.
• Clemson Tigers rank 6th in interceptions on defense this season with 5 interceptions.

Duke vs Clemson Preview

The Duke Blue Devils will visit the Clemson Tigers in a Week 10 game of the 2025 season. Duke holds a 4-3 record, with a 3-1 mark in conference play. They are on a one-game losing streak, and their last game was a loss. Duke’s road performance has been strong with a 2-1 record away from home.

Clemson, on the other hand, is 3-4 overall and 2-3 in the conference. They have struggled at home, posting a 1-3 record at Memorial Stadium. Both teams are eager to improve their standings in the Atlantic Coast Conference. Fans can expect a competitive game as both teams aim to break their current losing streaks.

Clemson Tigers’ Season Overview

The Clemson Tigers compete in the Atlantic Coast Conference. They play their home games at Memorial Stadium in Clemson, South Carolina. This season, the Tigers have a record of 3-4, with a home record of 1-3.

Clemson’s top quarterback, Cade Klubnik, has played in six games. He has thrown for 1,530 yards and 11 touchdowns. Klubnik is currently questionable with an ankle injury.

On the ground, Adam Randall leads the rushing attack. He has gained 433 rushing yards and scored four touchdowns in seven games. Injuries might impact the team’s performance, with several players listed as out or questionable.

Duke Blue Devils’ Team Overview

Duke Blue Devils are in the Atlantic Coast Conference. They play at Wallace Wade Stadium. This season, they have a record of 4-3 and a road record of 2-1.

Darian Mensah leads Duke’s offense. He has passed for 2,211 yards and 17 touchdowns in seven games. Mensah is ranked first in his team for passing yards and touchdowns.

Nate Sheppard is a key player in Duke’s ground game. He has rushed for 497 yards and four touchdowns in seven games. Duke’s team offense has gained 2,233 passing yards and 1,033 rushing yards this season.

Final Betting Pick

Duke has shown strong performance on the road this season with a 2-1 record. This makes them a good pick for the money line at +142. Clemson, on the other hand, has struggled at home with a 1-3 record. This gives Duke an advantage in this game.

For the over/under prediction, the total is set at 55.5. Duke’s recent games as an underdog have all gone over the total. Both teams have offenses that can score, with Duke ranked 18th in passing yards. This suggests the game could be high-scoring, making the over a solid choice.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.