Iowa Hawkeyes vs USC Trojans NCAAF Betting Prediction
PublishedNovember 11, 2025,            Posted By: Maria Uebelhor
Last updated:November 11, 2025 ,

NCAAF Iowa Hawkeyes vs USC Trojans Prediction 11/15

The Iowa Hawkeyes will take on the USC Trojans in Week 12 of the 2025 regular season. The game is set for Saturday, November 15, 2025, at 3:30 PM. It will be held at the Los Angeles Memorial Coliseum in Los Angeles, CA, and will air on BTN.

Iowa vs. USC Betting Prediction

  • Money Line Prediction: USC Trojans -253. USC is undefeated at home this season with a 5-0 record. Their strong home performance makes them a solid pick.
  • Over/Under Prediction: Over 49.5. USC’s offense ranks 11th in points scored, and Iowa’s defense has allowed points in recent games, suggesting a higher scoring game.

Team Trends

  • USC Trojans have a perfect home record this season, winning all 5 home games.
  • Iowa Hawkeyes have a road record of 2-1 this season.
  • USC Trojans rank 11th in points scored this season with 356 points.
  • Iowa Hawkeyes have allowed 123 points this season, ranking 52nd in points against.
  • The last postseason game for USC was a win against Texas A&M Aggies in the SRS Distribution Las Vegas Bowl.

Iowa vs USC Preview

The Iowa Hawkeyes, with a 6-3 record, are heading to Los Angeles to face the USC Trojans. Iowa is looking to improve their standing in the Big Ten. Their road record of 2-1 shows they can compete away from home. However, they are coming off a loss and need a win to boost their season.

USC, ranked 17th in the AP poll, holds a 7-2 record and is strong at home with a 5-0 record. They are on a two-game win streak, which gives them momentum. The Trojans rank fifth in the conference, just ahead of Iowa. Both teams are in the Big Ten, so this game is important for conference standings.

USC Trojans: Strong Season Start

The USC Trojans hold a record of 7-2 this season. They have been perfect at home, winning all five games. In conference play, they have a 5-1 record, showing their strength in the Big Ten.

Jayden Maiava leads the Trojans as the top quarterback. He has thrown for 2,614 yards in nine games, with 17 touchdowns and six interceptions. King Miller is the standout running back, with 636 rushing yards and five touchdowns in eight games.

Makai Lemon is the top wide receiver for USC. He has 61 receptions for 937 yards and seven touchdowns. The Trojans’ defense has also performed well, with 24 sacks and nine interceptions this season.

Iowa Hawkeyes: Battling Through the Season

The Iowa Hawkeyes have a 6-3 record this season. They have done well on the road, winning two out of three games. In the Big Ten, they hold a 4-2 record, showing they can compete.

Mark Gronowski leads Iowa’s passing game. He has 1,084 passing yards and five touchdowns in nine games. Kamari Moulton stands out in the running game, with 522 rushing yards and two touchdowns across seven games.

The Hawkeyes’ defense has been solid, with 17 sacks and 10 interceptions this season. Drew Stevens, the kicker, is consistent, making 17 field goals in nine games. Iowa’s recent game was a close 16-18 loss to Oregon.

Final Betting Pick

USC has been strong at home with a perfect 5-0 record this season. Their offense ranks 11th in points scored, which is a key factor in their success. Playing at the Los Angeles Memorial Coliseum gives them an edge, making them a good choice for the money line pick.

The over/under prediction of over 49.5 points is supported by USC’s high-scoring offense. Iowa’s defense has allowed points in recent games, which could lead to a higher score. With USC’s offensive strength and Iowa’s recent defensive performances, a high-scoring game is likely. This makes the over a reasonable pick.

If you love football and love a big win even more, our new Parlay Cards are your game-changer. Available now for College Football and NFL parlay betting, you can pick 5, 10, or 15 games and play for massive payouts with as little as $1. Where else can you turn pocket change into a million-dollar prize? Only at Action 24/7. Bet the old school way. Win the new school way.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.