Louisville Cardinals vs Virginia Tech Hokies NCAAF Betting Prediction
PublishedOctober 28, 2025,            Posted By: Maria Uebelhor
Last updated:October 28, 2025 ,

NCAAF Louisville Cardinals vs Virginia Prediction 11/1

The Louisville Cardinals will take on the Virginia Tech Hokies in Week 10 of the 2025 regular season. The game is set for Saturday, November 1, 2025, at 3:00 PM. It will be held at Lane Stadium in Blacksburg, VA, and aired on CW.

Louisville vs. Virginia Tech Betting Prediction

  • Money Line Prediction: Louisville Cardinals -413. Louisville has a strong record this season, especially in away games, where they are undefeated. Their recent performance against Boston College shows their ability to win on the road.
  • Over/Under Prediction: Over 53.5. Both teams have shown the ability to score, with Louisville’s recent games often going over 50 points. Virginia Tech’s last game also had a high score, suggesting a trend towards higher totals.

Team Trends

  • Louisville Cardinals are ranked #16 in the AP Poll and #17 in the Coaches Poll.
  • Virginia Tech Hokies have a home record of 2-4 this season.
  • Louisville Cardinals have an undefeated road record of 2-0 this season.
  • Virginia Tech Hokies recently won against California Golden Bears with a score of 42-34 at Lane Stadium.
  • Louisville Cardinals scored 242 points this season, ranking 41st in the nation.

Louisville vs Virginia Tech Preview

The Louisville Cardinals are heading into Week 10 with a strong record of 6-1. They are ranked 16th in the AP poll and 17th in the Coaches Poll. Their conference record stands at 3-1, and they are on a two-game win streak. This game is crucial for maintaining their position in the Atlantic Coast Conference standings. Louisville has shown strength on the road with a 2-0 record this season.

On the other side, the Virginia Tech Hokies have a 3-5 record. They hold a 2-2 conference record and are coming off a win. Virginia Tech is looking to improve their home performance, as they have a 2-4 record at Lane Stadium. This game against a ranked opponent like Louisville is a chance for the Hokies to make a statement. Both teams will be eager to showcase their skills on the field.

Virginia Tech Hokies Overview

The Virginia Tech Hokies are part of the Atlantic Coast Conference. They play their home games at Lane Stadium. Their current season record stands at 3-5, with a 2-4 record at home.

Kyron Drones is the leading quarterback for the Hokies. He has 1,516 passing yards, 14 touchdowns, and 6 interceptions in 8 games. Marcellous Hawkins leads the running backs with 531 rushing yards and 1 touchdown in 8 games.

On the defensive side, the Hokies have allowed 239 points this season. They have recorded 17 sacks and 5 interceptions. They are strong in fumble recoveries, with 2 for the season.

Louisville Cardinals: A Strong Contender

The Louisville Cardinals are ranked #16 in the AP Poll and #17 in the Coaches Poll. They have a strong record this season, standing at 6-1 overall. On the road, they are undefeated with a 2-0 record.

Miller Moss leads the team as the top quarterback. He has thrown for 1,793 yards and 10 touchdowns in 7 games. Isaac Brown is the leading rusher with 652 yards and 4 touchdowns in the same number of games.

On defense, the Cardinals have allowed 150 points this season. They have recorded 16 sacks and 12 interceptions. They are also skilled in recovering fumbles, with 4 in total.

Final Betting Pick

The Louisville Cardinals are favored on the money line at -413. This is a strong pick because they have a 6-1 record this season and are undefeated in road games. Their recent win against Boston College shows they can perform well away from home. Louisville’s consistent performance makes them a reliable choice for this game.

The over/under is set at 53.5, and taking the over seems wise. Louisville’s recent games have often exceeded 50 points. Virginia Tech’s last game also had a high score, with a 42-34 win over California. Both teams have shown they can score, making the over a solid option for this matchup.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.