LSU Tigers vs Vanderbilt Commodores NCAAF Betting Prediction
PublishedOctober 14, 2025,            Posted By: Maria Uebelhor
Last updated:October 14, 2025 ,

NCAAF LSU Tigers vs Vanderbilt Commodores Prediction 10/18

The LSU Tigers will take on the Vanderbilt Commodores on Saturday, October 18, 2025, at FirstBank Stadium in Nashville, TN. The game kicks off at 12:00 PM ET and will be broadcast on ABC. Both teams enter Week 8 of the season with a 5-1 record, making this a key game in the Southeastern Conference.

LSU vs. Vanderbilt Betting Prediction

  • Money Line Prediction: LSU Tigers +113. LSU is ranked higher and has a strong recent record. They have a good chance to win on the road.
  • Over/Under Prediction: Over 49.0. Vanderbilt’s recent home games have seen high scores, and both teams have strong offenses.

Team Trends

  • The LSU Tigers are ranked #10 in both the AP and Coaches Polls.
  • Vanderbilt Commodores have a perfect home record this season at 3-0.
  • LSU Tigers have scored 155 points this season, ranking 62nd in the nation.
  • Vanderbilt Commodores have scored 259 points this season, ranking 7th in the nation.
  • The game will be played at FirstBank Stadium in Nashville, TN, and will air on ABC.

LSU vs Vanderbilt Preview

The LSU Tigers head to Nashville to face the Vanderbilt Commodores in a key SEC game. Both teams have a 5-1 record, but LSU holds the edge in rankings at #10 in both the AP and Coaches Polls. The Tigers have been strong at home, but their road record is 1-1. They are coming off a win and aim to improve their conference standing.

Vanderbilt is ranked #17 in the AP Poll and #18 in the Coaches Poll. The Commodores have a perfect 3-0 home record this season. However, they are looking to bounce back from a recent loss. This game is important for both teams as they fight for a higher spot in the conference rankings.

Vanderbilt Commodores: Home Team Overview

The Vanderbilt Commodores are ranked #17 in the AP Poll and #18 in the Coaches Poll. They are part of the Southeastern Conference and play their home games at FirstBank Stadium. Their current season record stands at 5-1, with a perfect 3-0 record at home.

Quarterback Diego Pavia has played in all 6 games, throwing for 1409 yards and 14 touchdowns. Running back Sedrick Alexander has rushed for 319 yards and 5 touchdowns in 6 games. Wide receiver Junior Sherrill leads the team with 23 receptions for 274 yards and 5 touchdowns.

The Commodores have scored 259 points this season, ranking 7th in points for. Their defense has allowed 116 points, and they rank 8th in sacks with 18 total. Injuries are a concern with several players, including Mark Davis and Marlon Jones, listed as questionable.

LSU Tigers: Away Team Insights

The LSU Tigers are ranked #10 in both the AP and Coaches Polls. They belong to the Southeastern Conference and have a season record of 5-1. On the road, their record is 1-1, showing they have had mixed results away from Tiger Stadium.

Quarterback Garrett Nussmeier has played in all six games, accumulating 1,411 passing yards and nine touchdowns. Running back Caden Durham has rushed for 283 yards and two touchdowns in five games. Wide receiver Barion Brown leads with 27 receptions for 261 yards and one touchdown.

LSU’s offense has scored 155 points, ranking 62nd, with 1,549 passing yards, placing them 46th. Their defense has been effective, allowing 71 points and securing 16 sacks, ranking 10th. Several key players are questionable due to injuries, including Aaron Anderson and Paul Mubenga.

Final Betting Pick

LSU has shown strong performance on the road, making them a good pick for the money line at +113. Their recent record of 5-1, with a road win, indicates they can handle away games. Ranked #10 in both the AP and Coaches Polls, LSU has a solid standing that supports their potential to win against Vanderbilt.

The over 49.0 prediction is supported by Vanderbilt’s high-scoring home games. Vanderbilt has scored big at home, like their 70-21 win over Georgia State. Both teams have strong offenses, with Vanderbilt ranked 7th in points for the season. This suggests a high-scoring game is likely, making the over a good choice.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.