The Penn State Nittany Lions will play against the Ohio State Buckeyes on Saturday, November 1, 2025. This game is part of Week 10 of the regular season. It will take place at Ohio Stadium in Columbus, OH, and will be broadcast on FOX at 12:00 PM.

Penn State vs. Ohio State Betting Prediction

• Money Line Prediction: Ohio State -1705. Ohio State is strong at home with a 4-0 record this season. Penn State has struggled on the road, losing both away games.
• Over/Under Prediction: Under 43.5. Ohio State’s defense is solid, allowing only 41 points this season. Penn State’s offense has not been consistent, which could keep the score low.

Team Trends

• Ohio State Buckeyes hold the top rank in both the AP and Coaches Polls.
• Penn State Nittany Lions have not won an away game this season, with a 0-2 road record.
• Ohio State Buckeyes have a perfect 4-0 home record this season.
• Penn State Nittany Lions have lost their last four games, including a close 25-24 loss to Iowa.
• Ohio State Buckeyes’ defense ranks 9th in points against, allowing only 41 points this season.

Penn State vs Ohio State Preview

The Penn State Nittany Lions are heading into a challenging game against the Ohio State Buckeyes. Penn State has a 3-4 record this season, with a tough 0-4 standing in conference games. They have not won a game on the road yet, making this matchup even more critical. Their recent postseason game saw them narrowly lose to Notre Dame, which might add some motivation to turn things around.

Ohio State is sitting at the top with a perfect 7-0 record. They are ranked number one in both the AP and Coaches Polls. The Buckeyes have been strong at home, winning all four games played there. Their last postseason game ended with a victory over Notre Dame, showing their strength. With a seven-game win streak, Ohio State looks to maintain their momentum against Penn State.

Ohio State Buckeyes: Leaders on the Field

Ohio State Buckeyes hold the top spot in the AP and Coaches Polls. They play in the Big Ten Conference and call Ohio Stadium their home. The Buckeyes have a strong 7-0 record this season, with a perfect 4-0 at home and 4-0 in conference games.

Julian Sayin is a standout at quarterback for Ohio State, leading the team with 1,872 passing yards and 19 touchdowns over seven games. Bo Jackson has made an impact as a running back with 433 rushing yards and two touchdowns. Jeremiah Smith shines as a wide receiver with 49 receptions and 602 receiving yards.

On the defensive side, Ohio State has only allowed 41 points this season, ranking them 9th in points against. They have recorded 21 sacks and 4 interceptions, placing them 10th and 5th in the nation, respectively. Ohio State’s offense has scored 255 points, and their last win was a 34-0 victory over Wisconsin.

Penn State Nittany Lions: Ready for Battle

Penn State Nittany Lions compete in the Big Ten Conference and play home games at Beaver Stadium. This season, they hold a 3-4 record, including a 0-2 record on the road. In conference games, the Nittany Lions have faced challenges, standing at 0-4.

At quarterback, Drew Allar has been a key player, though he will miss the rest of the season due to injury. In six games, Allar threw for 1,100 yards and eight touchdowns. Kaytron Allen leads the rushing attack with 612 yards and nine touchdowns over seven games.

Penn State’s defense has allowed 136 points this season, ranking 62nd in points against. They have recorded 14 sacks and five interceptions, placing them 17th and 6th in the nation, respectively. The Nittany Lions are coming off a close 24-25 loss to Iowa and are 20.5-point underdogs against Ohio State.

Final Betting Pick

Ohio State’s money line at -1705 is a strong pick. They have a perfect 4-0 record at home this season. Ohio State’s defense has been tough, allowing only 41 points all season. This makes them a solid choice against Penn State, who has struggled on the road with a 0-2 record.

The under 43.5 is also a good pick. Ohio State’s defense ranks 9th in points against, which can keep the game low-scoring. Penn State’s offense has been inconsistent, which could make it difficult for them to score many points. With Ohio State’s defense being strong, the total score might stay under the predicted mark.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.