In Week 8 of the 2025 regular season, the Pittsburgh Panthers will play against the Syracuse Orange. The game will take place on Saturday, October 18, 2025, at 7:30 PM in the JMA Wireless Dome in Syracuse, NY. Fans can watch the game on ACCN.

Pittsburgh vs. Syracuse Betting Prediction

• Money Line Prediction: Pittsburgh Panthers -426. Pittsburgh has a strong record as a favorite, winning 23 of their last 30 games. They also recently defeated Florida State, showing they can win on the road.
• Over/Under Prediction: Over 54.5. Pittsburgh’s recent games have often gone over, with 5 of their last 7 games hitting the over. Syracuse has also seen high-scoring games, making the over a solid choice.

Team Trends

• Pittsburgh Panthers have a road record of 1-1 this season.
• Syracuse Orange have a home record of 2-2 this season.
• Pittsburgh Panthers won their last game against Florida State Seminoles with a score of 34-31.
• Syracuse Orange lost their last home game against Duke Blue Devils with a score of 38-3.
• The game will be played at the JMA Wireless Dome in Syracuse, NY.

Pittsburgh vs Syracuse Preview

The Pittsburgh Panthers head into Week 8 with a 4-2 record. They have a 2-1 record in conference games. Pittsburgh is on a 2-game win streak, which gives them momentum. They stand 6th in their conference. The Panthers have shown strength at home but are 1-1 on the road.

On the other side, the Syracuse Orange have a 3-3 record. They are 1-2 in conference games. Syracuse is on a 2-game losing streak, which they hope to break at home. The Orange are ranked 12th in their conference. At home, they have a balanced 2-2 record. Both teams are unranked in the AP and Coaches polls.

Key Players and Injuries

Syracuse Orange has shown strong performances from top players like quarterback Steve Angeli and running back Yasin Willis. Angeli leads with 1,352 passing yards and 10 touchdowns but is out for the season due to an Achilles injury. Willis contributes with 337 rushing yards and 4 touchdowns, providing strength in the running game.

The team faces challenges with injuries, as several key players are out. Along with Angeli, Tyshawn Russell and Julian McFadden will miss the rest of the season. Other players like Derek McDonald and Rashard Perry are questionable for the upcoming games.

Their injury list impacts their depth, especially on offense. Players like Rickie Collins and Will Nixon will need to step up. As the season progresses, their ability to adapt will be crucial for success.

Team Performance and Season Stats

Syracuse Orange holds a 3-3 record this season. At home, they are 2-2, playing in the Atlantic Coast Conference at the JMA Wireless Dome. Their conference record stands at 1-2, indicating some room for improvement.

The team has scored 174 points this season, ranking 48th in offense. They have a strong passing game with 1,924 yards, placing them 7th. However, their rushing yards rank 112th, which could be an area to improve.

Defensively, Syracuse has allowed 179 points, ranking them 107th in points against. They have recorded 8 sacks and 4 interceptions, showing some defensive strength. The team will look to tighten up their defense as they continue their season.

Betting Trends and Recent Performance

Syracuse is coming off a loss against SMU, with a score of 18-31. Despite the setback, their recent betting trends show potential. As underdogs, they have a strong record of 7-4 against the spread in their last 11 games.

At home, the team has a solid record of 18-7 in their last 25 games. They are also 19-1 in their last 20 games as favorites, showcasing their strength in favorable matchups. Their performance in games with totals of 50 points or more stands at 10-5.

Looking ahead, Syracuse will aim to bounce back from their recent loss. Key trends indicate they perform well after losses, with a 6-1 record in such situations. As they take on upcoming opponents, these trends provide insight into their potential success.

Pittsburgh Panthers: Strong Season and Key Players

The Pittsburgh Panthers are having a solid season with a 4-2 record. They have performed well at home with a 3-1 record and are even on the road at 1-1. In conference play, they hold a 2-1 record, which shows their ability to compete in the Atlantic Coast Conference.

Quarterback Eli Holstein is a key player for the Panthers. He has thrown for 1,058 passing yards and 11 touchdowns in just five games. Running back Ja’Kyrian Turner adds to their offense with 182 rushing yards and four touchdowns over five games.

Injury concerns exist for the Panthers, with players like Derrick Davis Jr. out for the season. Several others, such as Blaine Spires and Nilay Upadhyayula, are questionable. The team has depth, but these injuries may test their roster in upcoming games.

Final Betting Pick

The Pittsburgh Panthers are a strong pick for the money line at -426. They have a solid record as favorites, winning 23 of their last 30 games. Their recent victory over Florida State shows they can perform well on the road.

The over 54.5 is a good choice for this game. Pittsburgh’s recent games have often gone over, with 5 of their last 7 hitting the over. Syracuse has also had high-scoring games, making it likely for the total points to exceed 54.5.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.