SMU Mustangs vs Clemson Tigers NCAAF Betting Prediction
PublishedOctober 14, 2025,            Posted By: Maria Uebelhor
Last updated:October 14, 2025 ,

NCAAF SMU Mustangs vs Clemson Tigers Prediction 10/18

On Saturday, October 18, 2025, the SMU Mustangs will visit the Clemson Tigers at Memorial Stadium in Clemson, SC. This Week 8 game of the 2025 regular season is set to start at 3:30 PM and will be broadcast on ACCN. Both teams are part of the Atlantic Coast Conference, and fans can expect an exciting game on the outdoor field.

SMU vs. Clemson Betting Prediction

  • Money Line Prediction: SMU Mustangs +271. SMU has been strong on the road with an 11-1 record in their last 12 away games. This makes them a good value pick against Clemson.
  • Over/Under Prediction: Under 55.5. Clemson’s last home game went under the total, and their defense ranks well, making the under a solid choice.

Team Trends

  • SMU Mustangs have a road record of 1-1 this season.
  • Clemson Tigers have a home record of 1-2 this season.
  • SMU Mustangs’ defense ranks 7th in sacks with 19 this season.
  • Clemson Tigers’ offense ranks 29th in passing yards with 1,673 this season.
  • The game will be played at Memorial Stadium in Clemson, SC, on October 18, 2025.

SMU vs Clemson Preview

The SMU Mustangs come into Week 8 with a 4-2 record. They have a perfect conference record of 2-0. On the road, they stand at 1-1. They are on a two-game win streak and rank 4th in the conference. Last season, they reached the College Football Playoff First Round but fell to Penn State.

The Clemson Tigers hold a 3-3 record this season. Their conference record is 2-2, and they have struggled at home with a 1-2 record. Like SMU, they are also on a two-game win streak. They rank 10th in the conference. In their last postseason game, they lost to Texas in the College Football Playoff First Round.

Clemson Tigers: Home Team Overview

The Clemson Tigers play in the Atlantic Coast Conference. They call Memorial Stadium in Clemson, SC, their home. This season, they hold a 3-3 record overall, with a 1-2 record at home.

Cade Klubnik leads the team as a quarterback with significant stats. He has thrown for 1,530 yards, placing first on the team and 29th in the league. Klubnik also has 11 passing touchdowns and 117.6 fantasy points, both ranking first on the team.

On the ground, Adam Randall is the standout player for Clemson. He has rushed for 404 yards and scored four rushing touchdowns. Randall also contributes to the passing game with 19 receptions for 163 yards.

SMU Mustangs: A Road Test

The SMU Mustangs are part of the Atlantic Coast Conference, and they play home games at Gerald J. Ford Stadium. This season, they have a record of 4-2 overall and a 1-1 record in away games. In their last game, they secured a 34–10 victory over Stanford.

Kevin Jennings is the leading quarterback for SMU. He has thrown for 1,658 yards, which is first on the team. Jennings also has 15 passing touchdowns and six interceptions, earning him 120.9 fantasy points.

TJ Harden is the top running back for the Mustangs. He has rushed for 414 yards and scored five rushing touchdowns. On the receiving end, Romello Brinson stands out with 32 receptions for 484 yards and three touchdowns.

Final Betting Pick

SMU’s money line at +271 is an attractive pick due to their recent success on the road. They have won 11 out of their last 12 away games, showing they can perform well outside their home stadium. This strong road record makes them a solid choice against Clemson, especially with Clemson’s current home record of 1-2 this season.

The under 55.5 points is a reasonable bet given Clemson’s defensive performance. In their last home game, they held the total under, and their defense is ranked well this season. SMU’s defense is also performing well, ranking 7th in sacks and 11th in interceptions, which can help keep the score low.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.