The USC Trojans will take on the Oregon Ducks in Week 13 of the 2025 regular season. This game will be held at Autzen Stadium in Eugene, OR, on Saturday, November 22, 2025, at 3:30 PM. Fans can catch the game on CBS as these two Big Ten teams battle it out on the outdoor field.

USC vs. Oregon Betting Prediction

• Money Line Prediction: USC Trojans +298. USC has shown strength in recent away games, winning against Nebraska. Their current rank and past performances suggest they could pull an upset.
• Over/Under Prediction: Over 59.5. Both teams have strong offenses, with Oregon scoring 42 in their last game and USC consistently putting up points. This suggests a high-scoring game.

Team Trends

• USC Trojans are ranked #16 in both the AP and Coaches Polls.
• Oregon Ducks have a strong home record of 5-1 this season.
• USC Trojans have a road record of 2-2 this season.
• Oregon Ducks are ranked #6 in the AP Poll and #5 in the Coaches Poll.
• USC Trojans won their last postseason game against Texas A&M Aggies, 35-31.

USC vs Oregon Preview

The USC Trojans are heading to Eugene with an 8-2 record this season. They are ranked 16th in both the AP and Coaches Poll. The Trojans have been strong in the conference with a 6-1 record. They are on a 3-game win streak, which they hope to extend against the Ducks.

The Oregon Ducks stand at 9-1 and hold a high ranking of 6th in the AP Poll. They have a solid conference record of 6-1 and are on a 4-game win streak. Playing at Autzen Stadium, the Ducks have only lost once at home this season. This game is crucial for both teams as they look to improve their standings in the Big Ten.

Oregon Ducks: Season Snapshot

The Oregon Ducks are ranked #6 in the AP Poll and #5 in the Coaches Poll. They play in the Big Ten Conference and their home games are at Autzen Stadium. This season, their record is 9-1, with a strong 5-1 record at home and 4-0 on the road.

Dante Moore is leading the team at quarterback with 2,190 passing yards and 21 touchdowns over 10 games. Jordon Davison stands out as a top running back, achieving 461 rushing yards and 12 touchdowns. Dakorien Moore is a notable wide receiver with 443 receiving yards and 3 touchdowns.

The Ducks have scored 390 points this season, ranking 10th in points for. Their defense has allowed 137 points, placing them 55th in points against. Oregon’s defense has also recorded 17 sacks and 9 interceptions, showcasing their strong defensive performance.

USC Trojans: Analyzing the Season

USC Trojans are ranked #16 in both the AP and Coaches Polls. They play in the Big Ten Conference, with home games at the Los Angeles Memorial Coliseum. This season, they hold an 8-2 record, with a perfect 6-0 at home and 2-2 on the road.

Quarterback Jayden Maiava has passed for 2,868 yards with 18 touchdowns in 10 games. King Miller leads the rushing attack with 719 yards and 5 touchdowns over 9 games. Wide receiver Makai Lemon shines with 1,090 receiving yards and 8 touchdowns.

The Trojans have scored 382 points this season, ranking 13th in points for. Their defense has allowed 217 points, placing them 78th in points against. USC’s defense has notched 24 sacks and 10 interceptions this season.

Final Betting Pick

USC Trojans have shown they can perform well on the road. They recently secured a win against Nebraska, demonstrating their ability to handle away games. With a strong passing attack ranked 13th in the nation, USC has the potential to challenge Oregon’s defense. Betting on USC with a money line of +298 could be a smart choice for those looking for an upset.

The over/under prediction of over 59.5 points is also reasonable. Both teams have potent offenses, with Oregon scoring 42 points in their last game. USC has consistently put up points, ranking 13th in passing yards. This suggests that both teams are likely to score a lot, making the over a good bet for this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.