Atlanta Falcons vs Arizona Cardinals NFL Betting Prediction
PublishedDecember 17, 2025,            Posted By: Maria Uebelhor
Last updated:December 17, 2025 ,

NFL Atlanta Falcons vs Arizona Cardinals Prediction 12/21

The Atlanta Falcons will play against the Arizona Cardinals on Sunday, December 21, 2025. The game will take place at State Farm Stadium in Glendale, AZ, with kickoff at 4:05 PM. Fans can watch the game on FOX, and the weather is expected to be mild with broken clouds.

Falcons vs. Cardinals Betting Prediction

  • Money Line Prediction: Falcons -148. The Falcons have a better road record at 3-5 compared to the Cardinals’ home record of 1-6. This gives the Falcons an edge in this game.
  • Over/Under Prediction: Over 47.5. Both teams have shown they can score, with the Cardinals scoring 20 or more points in their last two games. The Falcons also scored 29 points in their last game.

Team Trends

  • The Atlanta Falcons have a road record of 3-5-0 this season.
  • Arizona Cardinals have struggled at home with a record of 1-6-0.
  • Kirk Cousins led the Falcons to a 29-28 win over the Tampa Bay Buccaneers in their last away game.
  • In Week 15, the Cardinals lost 40-20 to the Houston Texans on the road.
  • Jacoby Brissett threw for 452 yards in a recent Cardinals home game against the San Francisco 49ers.

Falcons vs Cardinals Preview

The Atlanta Falcons head to Arizona to take on the Cardinals in Week 16 of the 2025 NFL season. The Falcons are currently third in the NFC South with a record of 5-9. They are coming off a win and will look to continue their momentum. Quarterback Kirk Cousins is expected to throw for over 230 yards, while rookie running back Bijan Robinson could make a significant impact with nearly 100 rushing yards.

The Arizona Cardinals, sitting at the bottom of the NFC West with a 3-11 record, are eager to snap their six-game losing streak. Quarterback Jacoby Brissett is projected to pass for over 240 yards, which could help the Cardinals find some offensive rhythm. Key players like wide receiver Michael Wilson and tight end Trey McBride are also expected to contribute significantly to the Cardinals’ efforts.

Arizona Cardinals Gearing Up

The Arizona Cardinals are looking to improve their performance this season. Jonathan Gannon leads the team as head coach, aiming to turn around a 3-11 record. Playing at State Farm Stadium, the Cardinals hope to secure more wins at home.

Jacoby Brissett stands out as a key player for the Cardinals. He has thrown for 2,708 yards and 18 touchdowns in 11 games. This puts him first on the team in passing statistics for the regular season.

Among the receivers, Michael Wilson leads with 66 receptions and 766 yards. Trey McBride shines at tight end, with 105 receptions and 10 touchdowns. These players are crucial for the team’s offense going forward.

Atlanta Falcons Set for Battle

Raheem Morris leads the Atlanta Falcons as head coach. The Falcons have a 5-9 record this season. They have three wins on the road so far.

Kirk Cousins is the main quarterback for the Falcons. He is expected to throw for 238.3 yards and 1.6 touchdowns in the upcoming game. Bijan Robinson will also play a big role with 94.4 rushing yards projected.

Drake London is the top wide receiver for the team. He has racked up 810 receiving yards and six touchdowns in nine games. Kyle Pitts Sr. adds to the offense with 797 receiving yards and four touchdowns.

Final Betting Pick

The Falcons are a solid pick for the money line at -148. They have a better road record this season, winning three out of eight games. In their last road game, they scored 29 points against the Buccaneers, showing they can perform well away from home.

The over 47.5 points is also a good choice. The Cardinals have scored 20 or more points in their last two games, and the Falcons scored 29 points in their last outing. Both teams have shown they can put points on the board, making the over a reasonable expectation.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.