The Buffalo Bills take on the Carolina Panthers on Sunday, October 26, 2025, at 1:00 PM. The game will be held at Bank of America Stadium in Charlotte, NC, with FOX broadcasting the event. Fans can expect a cool day with overcast clouds for this Week 8 matchup.

Bills vs. Panthers Betting Prediction

• Money Line Prediction: Carolina Panthers +302. The Panthers have a strong home record of 3-0 this season. They have been solid at home, making them a good value pick.
• Over/Under Prediction: Under 46.5 (-116). Both teams have shown defensive strength in recent games, and the Panthers’ last game was low-scoring with a 13-6 win.

Team Trends

• The Carolina Panthers are undefeated at home this season with a 3-0-0 record.
• The Buffalo Bills have a 1-1-0 record on the road this season.
• In Week 6, the Panthers won a close game against the Dallas Cowboys with a score of 30-27.
• The Bills lost their last away game to the Atlanta Falcons with a score of 24-14.
• Rico Dowdle from the Panthers had an impressive 206 rushing yards in their Week 5 win against the Miami Dolphins.

Bills vs Panthers Preview

The Buffalo Bills, currently ranked second in the AFC East with a 4-2 record, are looking to bounce back from a two-game losing streak. They will face the Carolina Panthers, who hold a 4-3 record and are second in the NFC South. The Panthers have been strong at home, winning all three games in Charlotte this season.

Josh Allen is expected to lead the Bills with 237.5 passing yards and nearly two touchdowns. On the Panthers’ side, Andy Dalton is projected to throw for 190.7 yards and 1.4 touchdowns. The game will be played at Bank of America Stadium, where the Panthers aim to extend their winning streak to four games.

Carolina Panthers: Key Players and Game Insights

The Carolina Panthers, led by head coach Dave Canales, play in the NFC South. Their record this season is 4-3-0. They have done well at home, winning all three games at Bank of America Stadium.

Andy Dalton is set to start at quarterback for the Panthers in this game. He is projected to throw for 190.7 yards with 1.4 touchdowns. Rico Dowdle, at running back, is expected to add 68.5 rushing yards and 0.3 touchdowns.

Wide receiver Tetairoa McMillan leads the team with 61.6 receiving yards projected in this game. The team’s defense ranks 16th in sacks from the previous season. However, they aim to improve from the 32nd rank in opponent offensive yards allowed.

Buffalo Bills: Players to Watch and Game Analysis

Josh Allen will lead the Buffalo Bills as the starting quarterback. Allen is expected to throw for 237.5 yards and score 1.9 touchdowns. He has zero interceptions projected for this game, highlighting his accuracy.

Running back James Cook is another key player for the Bills. Cook is projected to rush for 81.8 yards with 0.8 touchdowns. His ability to catch passes also adds to his value, with 2.2 receptions expected.

The Bills are coached by Sean McDermott and play in the AFC East. They have a 4-2-0 record this season. On the road, they have managed a 1-1-0 record, showing they can compete away from home.

Final Betting Pick

The Carolina Panthers are a strong pick with a money line of +302. They have a perfect home record of 3-0 this season. This shows they perform well at Bank of America Stadium. Their recent win against the Dallas Cowboys at home also boosts their confidence. The under 46.5 prediction is backed by both teams’ recent defensive performances. The Panthers’ last game was a low-scoring 13-6 win. This indicates they can keep games tight and low in points. The Buffalo Bills have also shown defensive strength, which might limit scoring opportunities.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.