The Buffalo Bills will take on the Houston Texans on Thursday, November 20, 2025. This Week 12 game will be held at NRG Stadium in Houston, TX, starting at 8:15 PM. Fans can catch the action on AMZN as the Bills, with a 7-3 record, aim to continue their winning streak against the 5-5 Texans. The weather forecast predicts a warm day with light rain, but the retractable roof at the stadium may keep the field conditions unaffected.

Bills vs. Texans Betting Prediction

• Money Line Prediction: Buffalo Bills -277. The Bills have a strong record this season and have performed well on the road. They have a balanced offense led by Josh Allen, and their defense ranks well in interceptions.
• Over/Under Prediction: Over 43.5. Both teams have shown they can score, with the Bills recently scoring 44 against the Buccaneers and the Texans scoring 36 against the Jaguars. The total should go over given their recent performances.

Team Trends

• The Buffalo Bills have a road record of 2-2-0 this season.
• The Houston Texans have a home record of 3-2-0 this season.
• Buffalo’s last game was a 44-32 win against the Tampa Bay Buccaneers.
• Houston’s last game was a 16-13 win against the Tennessee Titans.
• Buffalo’s head coach is Sean McDermott, while Houston’s head coach is DeMeco Ryans.

Bills vs Texans Preview

The Buffalo Bills are ready to meet the Houston Texans in a Week 12 game at NRG Stadium. The Bills hold a 7-3 record and are second in the AFC East. They aim to keep up with the Patriots at the top of the division. The Texans, with a 5-5 record, are third in the AFC South. They look to improve their standing in a competitive division.

Josh Allen leads the Bills’ offense with projections of 231.2 passing yards and 1.7 touchdowns. James Cook is expected to add 80.9 rushing yards. For the Texans, Davis Mills is projected to throw for 179.9 yards with 1.2 touchdowns. Woody Marks might contribute 58.1 rushing yards. Both teams will rely on their key players to make an impact in this game.

Houston Texans: Team Overview

The Houston Texans hold a 5-5 record this season, with a 3-2 record at home. They are part of the AFC South and play their home games at NRG Stadium. DeMeco Ryans leads the team as the head coach.

Davis Mills is projected to lead the offense this week with 179.9 passing yards and 1.2 touchdowns. On the ground, Woody Marks is expected to gain 58.1 rushing yards and add 0.5 touchdowns. Nico Collins could be a key player with 68.8 receiving yards and 0.5 touchdowns projected.

Last season, the Texans ranked 18th in scoring and 21st in passing yards. Their defense performed well, ranking 13th in opponent score and 4th in sacks. This week, they will be missing key players like C.J. Stroud and several others due to injuries.

Buffalo Bills Set for a Texas Showdown

Josh Allen leads the Buffalo Bills offense, projected to throw for 231.2 passing yards and 1.7 touchdowns. James Cook is expected to carry the ball for 80.9 rushing yards and might score a touchdown. The Bills’ passing game features Khalil Shakir, who could gain 50.7 receiving yards.

Sean McDermott is the head coach of the Bills. They are part of the AFC East and have a 7-3 record this season. The team plays their home games at Highmark Stadium, but this week they will be on the road with a 2-2 away record.

Last season, the Bills ranked second in scoring and ninth in passing yards. Their defense was strong, finishing eleventh in opponent scoring and tenth in sacks. Key players like Ed Oliver and Taylor Rapp are out due to injuries, which could affect their performance.

Final Betting Pick

The Buffalo Bills are a solid pick on the money line at -277. They have a strong road record and a balanced offense led by Josh Allen. Allen is projected to throw for over 230 yards and nearly two touchdowns, which should help the Bills maintain their winning form. The Bills’ defense is also effective, ranking well in interceptions, which could create turnovers against the Texans.

The over 43.5 points prediction looks promising given both teams’ recent scoring. The Bills scored 44 points against the Buccaneers, and the Texans put up 36 against the Jaguars. Both teams have shown they can move the ball effectively. With Davis Mills projected to throw for nearly 180 yards and the Texans’ strong home record, the game could see plenty of scoring opportunities.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.