Indianapolis Colts vs Jacksonville Jaguars NFL Betting Prediction
PublishedDecember 3, 2025,            Posted By: Maria Uebelhor
Last updated:December 3, 2025 ,

NFL Colts vs Jacksonville Jaguars Prediction 12/7

On Sunday, December 7, 2025, the Indianapolis Colts will travel to face the Jacksonville Jaguars at EverBank Stadium in Jacksonville, FL. Both teams have an 8-4 record this season, making this game important for the AFC South standings. The game will start at 1:00 PM and will be broadcast on CBS. Weather conditions for the game day are not available.

Colts vs. Jaguars Betting Prediction

  • Money Line Prediction: Jaguars +108. The Jaguars have a strong home record of 4-2-0 and are coming off a big win against the Titans. This makes them a good value at home.
  • Over/Under Prediction: Under 47.5 (-109). Both teams have shown solid defensive performances recently, suggesting a lower-scoring game.

Team Trends

  • The Indianapolis Colts have an away record of 2-3 this season.
  • The Jacksonville Jaguars hold a home record of 4-2 this season.
  • Both the Colts and Jaguars share a division record of 2-1 in the AFC South.
  • In their most recent game, the Colts lost to the Houston Texans 20-16.
  • The Jaguars recently defeated the Tennessee Titans 25-3 in an away game.

Colts vs Jaguars Preview

The Indianapolis Colts and Jacksonville Jaguars are set to meet in an important AFC South game. Both teams have an 8-4 record, making this game key for division standings. The Colts are on a two-game losing streak, while the Jaguars have won their last three games. This game will be at EverBank Stadium, where the Jaguars have a strong 4-2 home record.

For the Colts, quarterback Daniel Jones is projected to throw for 235.7 yards and 1.6 touchdowns. Running back Jonathan Taylor is expected to gain 100.5 rushing yards. The Jaguars will rely on quarterback Trevor Lawrence, who is projected to pass for 228.6 yards. Running back Travis Etienne Jr. could add 53.8 rushing yards. Both teams will aim to gain the upper hand in the division.

Jaguars Prepare for Game Day

The Jacksonville Jaguars have had a good season so far. They hold a record of 8-4-0 with a home record of 4-2-0. Head Coach Liam Coen has led the team well in the AFC South division.

Trevor Lawrence is the top quarterback for the Jaguars. He has thrown for 2,636 yards and 16 touchdowns this season. Running back Travis Etienne Jr. has also been strong, rushing for 843 yards and scoring 5 touchdowns.

The Jaguars have a few players on the injury list. Key players like Parker Washington and Arik Armstead are questionable for the upcoming game. However, others like Cooper Hodges and Travis Hunter are out for the season.

Colts Set for Road Challenge

The Indianapolis Colts are ready to take on the Jaguars. They have an 8-4-0 record this season and have won two of five road games. Head Coach Shane Steichen is guiding the team in the AFC South.

Quarterback Daniel Jones leads the Colts with 3,041 passing yards and 19 touchdowns. In the upcoming game, he is projected to throw for 235.7 yards and 1.6 touchdowns. Running back Jonathan Taylor is another key player, expected to gain 100.5 rushing yards.

The Colts have several players dealing with injuries. Notable players like DeForest Buckner and Sauce Gardner will miss upcoming games, while Anthony Richardson Sr. is out due to an eye injury. Despite these challenges, the Colts are focused on their next game.

Final Betting Pick

The Jaguars have a solid home record of 4-2-0, which makes them a good pick on the money line at +108. They recently won against the Titans, showing they can perform well at home. Trevor Lawrence is expected to pass for 228.6 yards, which could help the Jaguars maintain their strong home performance.

For the over/under prediction, the under 47.5 is a good choice. Both teams have been strong on defense recently. The Jaguars held the Titans to just 3 points, and the Colts have been consistent in keeping games under control. These factors suggest a lower-scoring game is likely.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.