Indianapolis Colts vs Los Angeles Chargers NFL Betting Prediction
PublishedOctober 15, 2025,            Posted By: Maria Uebelhor
Last updated:October 15, 2025 ,

NFL Colts vs Los Angeles Chargers Prediction 10/19

The Indianapolis Colts are set to play the Los Angeles Chargers on Sunday, October 19, 2025. The game will take place at SoFi Stadium in Inglewood, CA, and kick off at 4:05 PM. Fans can catch the action on CBS as the Colts, with a 5-1 record, take on the 4-2 Chargers in this Week 7 matchup.

Colts vs. Chargers Betting Prediction

  • Money Line Prediction: Colts +109. The Colts have a strong 5-1 record this season and have been solid on the road with a 1-1 record. Their recent games show they can score well, making them a good value pick.
  • Over/Under Prediction: Over 48.5 (-110). Both teams have shown they can score, with the Colts scoring over 30 points in three of their last five games. The Chargers also have a potent offense, making the over a strong choice.

Team Trends

  • The Indianapolis Colts have a 5-1-0 record this season, with a 1-1-0 record on the road.
  • The Los Angeles Chargers have a 4-2-0 record this season, with a 2-1-0 record at home.
  • In their last game, the Colts won against the Arizona Cardinals with a score of 31-27.
  • The Chargers recently defeated the Miami Dolphins 29-27 in an away game.
  • Jonathan Taylor of the Colts had 123 rushing yards and 1 touchdown in their last game against the Cardinals.

Colts vs Chargers Preview

The Indianapolis Colts are leading the AFC South with a 5-1 record. They have shown strength at home, winning all four home games. Daniel Jones, the Colts’ quarterback, is expected to pass for over 220 yards. Jonathan Taylor, their running back, aims to add nearly 100 rushing yards to his season total. The Colts are on a two-game winning streak, looking to extend it against the Chargers.

The Los Angeles Chargers hold the top spot in the AFC West with a 4-2 record. They have been solid both at home and on the road. Justin Herbert, the Chargers’ quarterback, is projected to throw for more than 246 yards. Ladd McConkey, a key wide receiver, could make a big impact with over 65 receiving yards. With a recent win, the Chargers aim to keep their momentum going at SoFi Stadium.

Chargers’ Season Overview and Key Players

The Los Angeles Chargers have a record of 4-2-0 this season. At home, they hold a 2-1-0 record. Their head coach is Jim Harbaugh, leading them from SoFi Stadium in the AFC West.

Justin Herbert is the top QB for the Chargers, leading the league in passing yards and touchdowns. He has thrown for 1,493 yards and 10 touchdowns over six games. His fantasy points stand at 107.2, ranking him first in the team.

Quentin Johnston is a top wide receiver for the Chargers, with 377 receiving yards and four touchdowns. Keenan Allen has 316 receiving yards and three touchdowns in six games. Cameron Dicker, the kicker, has made 14 field goals and 11 extra points this season.

Colts’ Strong Start and Key Contributors

The Indianapolis Colts have a record of 5-1-0 this season. On the road, they are 1-1-0. Shane Steichen is their head coach, guiding them in the AFC South from Lucas Oil Stadium.

Daniel Jones is the starting quarterback for the Colts. He has thrown for 1,502 yards and 8 touchdowns in six games. His fantasy points total 117.7, placing him at the top on the team.

Jonathan Taylor is a standout running back for the Colts. He has rushed for 603 yards and scored 7 touchdowns over six games. Michael Badgley, the kicker, has made 1 field goal and 4 extra points this season.

Final Betting Pick

The Colts are a solid pick for the money line at +109. They have a strong 5-1 record this season and have shown they can perform well on the road. With Daniel Jones projected to throw for over 220 yards and Jonathan Taylor expected to rush close to 100 yards, their offense is in good form.

For the over/under bet, the over 48.5 is a good choice. The Colts have scored over 30 points in three of their last five games, and the Chargers have a strong offense too. Justin Herbert is projected to pass for over 246 yards, which supports the likelihood of a high-scoring game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.