The San Francisco 49ers take on the Arizona Cardinals on Sunday, November 16, 2025. This Week 11 game will be held at State Farm Stadium in Glendale, AZ. The game starts at 4:05 PM and will be broadcast on FOX. Both teams are part of the NFC West division, making this an important game for standings. The 49ers have a 6-4 record, while the Cardinals are at 3-6.

49ers vs. Cardinals Betting Prediction

• Money Line Prediction: San Francisco 49ers -147. The 49ers have a better road record this season at 4-2. The Cardinals have struggled at home with a 1-3 record.
• Over/Under Prediction: Under 48.5. Both teams have shown strong defensive capabilities, and recent games have not consistently hit high scores.

Team Trends

• The San Francisco 49ers have a road record of 4-2-0 this season.
• The Arizona Cardinals have a home record of 1-3-0 this season.
• In their last game, the 49ers lost to the Los Angeles Rams with a score of 42-26.
• The Cardinals lost their last game against the Seattle Seahawks, 44-22.
• Christian McCaffrey of the 49ers had 106 rushing yards and 1 rushing touchdown against the New York Giants in Week 9.

49ers vs Cardinals Preview

The San Francisco 49ers will visit the Arizona Cardinals at State Farm Stadium. The 49ers are currently third in the NFC West with a 6-4 record. They are looking to improve their standing in the division. The Cardinals, with a 3-6 record, are at the bottom of the division. They aim to gain some momentum at home.

Quarterback Brock Purdy leads the 49ers with a projection of 245.5 passing yards and 1.6 touchdowns. Christian McCaffrey is expected to add 74.2 rushing yards. On the Cardinals’ side, Jacoby Brissett is projected to throw for 219.1 yards and 1.8 touchdowns. Marvin Harrison Jr. could be a key target, with 58.5 receiving yards projected. This game is important for both teams as they fight for better positions in the NFC West.

Arizona Cardinals: Home Team Insights

The Arizona Cardinals are guided by head coach Jonathan Gannon. They play in the NFC West and host games at State Farm Stadium. This season, the team holds a record of 3-6, with a 1-3 mark at home.

Jacoby Brissett leads the Cardinals as their top quarterback. He has played in six games, throwing for 1,118 yards and eight touchdowns. He is projected to add 219.1 passing yards and 1.8 touchdowns in the upcoming game.

On the ground, Emari Demercado is set as the leading running back. He is projected to gain 49.5 rushing yards and could score a touchdown. Wide receiver Marvin Harrison Jr. stands out with 525 receiving yards this season and is expected to add 58.5 yards to his total.

San Francisco 49ers: Road Warriors

The San Francisco 49ers are under the leadership of head coach Kyle Shanahan. They are part of the NFC West and play their home games at Levi’s Stadium. This season, the 49ers have a 6-4 record, with a 4-2 mark on the road.

Brock Purdy is set to be the starting quarterback, with a projected 245.5 passing yards and 1.6 touchdowns in the upcoming game. Christian McCaffrey leads the backfield, expected to gain 74.2 rushing yards and make 5.6 receptions. In the receiving corps, George Kittle stands out, projected to add 59.2 receiving yards and 0.5 touchdowns.

The 49ers’ offense ranks high, with 4234 passing yards last season, placing them 4th in the league. On defense, they face challenges, ranking 26th in opponent scores with 436 points allowed. Key injuries include Nick Bosa and Fred Warner, both out for the season.

Final Betting Pick

The 49ers have a solid road record at 4-2, which supports the money line prediction of San Francisco at -147. Brock Purdy is expected to throw for 245.5 yards, and Christian McCaffrey is projected to gain 74.2 rushing yards. These stats suggest the 49ers can perform well away from home.

The prediction for the game to go under 48.5 points is backed by both teams’ defensive strengths. The 49ers rank 8th in opponent offensive yards allowed, while the Cardinals rank 14th in opponent scores. Recent games for both teams have shown lower scoring trends, supporting the under prediction.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.