Jacksonville Jaguars vs Arizona Cardinals NFL Betting Prediction
PublishedNovember 19, 2025,            Posted By: Maria Uebelhor
Last updated:November 19, 2025 ,

NFL Jaguars vs Arizona Cardinals Prediction 11/23

The Jacksonville Jaguars will visit the Arizona Cardinals on Sunday, November 23, 2025. The game will take place at State Farm Stadium in Glendale, Arizona. Kickoff is set for 4:05 PM and will be broadcast on CBS. The weather forecast predicts a mild day with overcast clouds, but the retractable roof may minimize any wind impact.

Jaguars vs. Cardinals Betting Prediction

  • Money Line Prediction: Jacksonville Jaguars at -149. The Jaguars have a better record this season and are coming off a strong win against the Chargers. The Cardinals have struggled at home with a 1-4 record.
  • Over/Under Prediction: Over 47.5. Both teams have shown they can score, with the Jaguars scoring 35 in their last game and the Cardinals’ recent games also hitting high totals.

Team Trends

  • The Jacksonville Jaguars have a road record of 2-2 this season.
  • The Arizona Cardinals have won only 1 of their 5 home games this season.
  • In their last game, the Jaguars defeated the Los Angeles Chargers 35-6.
  • Arizona’s quarterback, Jacoby Brissett, threw for 452 yards and 2 touchdowns in their recent loss to the San Francisco 49ers.
  • The Cardinals have a division record of 0-4 this season.

Jaguars vs Cardinals Preview

The Jacksonville Jaguars are heading into Week 12 with a 6-4 record, sitting second in the AFC South. Trevor Lawrence leads the team with a projected 218.7 passing yards and 1.5 touchdowns for this game. Travis Etienne Jr. is expected to contribute on the ground with 62.1 rushing yards. The Jaguars look to build on their recent win as they face the Arizona Cardinals.

The Arizona Cardinals, with a 3-7 record, are at the bottom of the NFC West. Jacoby Brissett is projected to pass for 244.8 yards and 1.9 touchdowns. The Cardinals aim to break their two-game losing streak. Trey McBride could play a key role with a projection of 74 receiving yards. Both teams will compete under the controlled conditions of State Farm Stadium’s retractable roof.

Arizona Cardinals: Key Players and Season Overview

The Arizona Cardinals are led by head coach Jonathan Gannon. This season, they have a record of 3-7-0, with a home record of 1-4-0. The Cardinals play their home games at State Farm Stadium and compete in the NFC West division.

Quarterback Jacoby Brissett is expected to play a significant role in the upcoming game. He projects to pass for 244.8 yards and 1.9 touchdowns. Trey McBride stands out as the top tight end, with a projection of 74.0 receiving yards and 0.6 touchdowns.

The Cardinals have faced challenges this season, with multiple key players on injured reserve. Kyler Murray, James Conner, and Zay Jones are among those out for the remainder of the season. Despite these setbacks, the team looks to build on the strengths of players like Trey McBride and Marvin Harrison Jr.

Jacksonville Jaguars: Road Warriors Ready for Action

The Jacksonville Jaguars have a season record of 6-4-0. They are led by head coach Liam Coen and play in the AFC South. The Jaguars have done well at home with a 4-2-0 record, while their road record stands at 2-2-0.

Quarterback Trevor Lawrence is a key player for the Jaguars. He is projected to pass for 218.7 yards and 1.5 touchdowns in the upcoming game. Running back Travis Etienne Jr. is also expected to contribute with 62.1 rushing yards and 0.5 touchdowns.

The Jaguars face injury challenges with several players out or questionable. Brian Thomas Jr. and Brenton Strange are listed as questionable. Despite these issues, the team looks to maintain its strong performance and secure another win.

Final Betting Pick

The Jaguars are a strong pick for the money line at -149. They have a 6-4 record this season and recently won 35-6 against the Chargers. Their road record of 2-2 shows they can perform away from home. The Cardinals have struggled at home with a 1-4 record, making the Jaguars a safer choice.

The over 47.5 is a good bet as both teams have shown they can score. The Jaguars scored 35 in their last game, and the Cardinals have had high-scoring games recently. With both teams having strong offensive players, this game could easily exceed the total points set.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.