The Kansas City Chiefs are set to play against the Buffalo Bills on Sunday, November 2, 2025. This Week 9 game will take place at Highmark Stadium in Orchard Park, NY, with a kickoff time of 4:25 PM. Fans can catch the action on CBS. The Chiefs come in with a 5-3 record, while the Bills hold a 5-2 record this season.

Chiefs vs. Bills Betting Prediction

• Money Line Prediction: Buffalo Bills +110. The Bills have a strong home record of 3-1 this season. Their recent win against the Panthers shows they are performing well.
• Over/Under Prediction: Under 52.5 (-111). Both teams have solid defenses, with the Chiefs ranked 4th in opponent score and the Bills 11th. This could limit the total points scored.

Team Trends

• The Kansas City Chiefs have a road record of 1-2 this season.
• The Buffalo Bills have a home record of 3-1 this season.
• Patrick Mahomes threw for 299 yards and 3 touchdowns against the Washington Commanders in Week 8.
• James Cook rushed for 216 yards and scored 2 touchdowns against the Carolina Panthers in Week 8.
• The game will be played at Highmark Stadium in Orchard Park, NY.

Chiefs vs Bills Preview

The Kansas City Chiefs and Buffalo Bills are gearing up for a big game this Sunday. The Chiefs, with a 5-3 record, sit third in the AFC West. They are on a three-game winning streak, which adds momentum to their visit to Highmark Stadium. The Bills, at 5-2, hold second place in the AFC East. They are coming off a win and will look to maintain their strong home record.

Quarterbacks Patrick Mahomes and Josh Allen are key players to watch. Mahomes is projected to throw for 254.2 yards and 2 touchdowns. Allen is expected to pass for 219.9 yards and 1.8 touchdowns. Both teams have strong offensive weapons, with the Chiefs relying on Travis Kelce and the Bills on James Cook. The game promises to be a test of each team’s offensive and defensive strengths.

Buffalo Bills: Strengths on the Field

The Buffalo Bills have a strong lineup this season. Josh Allen leads the team as the top quarterback. He has thrown for 1,560 yards, placing him first in the team rankings.

James Cook stands out as the top running back. He has rushed for 753 yards and scored seven touchdowns in seven games. Khalil Shakir is the leading wide receiver, with 356 receiving yards.

Under the guidance of head coach Sean McDermott, the Bills have a solid record of 5-2-0. They have won three out of four games at home. The team plays in the AFC East and calls Highmark Stadium their home.

Kansas City Chiefs: Road Warriors Ready for Battle

Patrick Mahomes is the key player for the Kansas City Chiefs. He has 2,099 passing yards and 17 touchdowns this season. Mahomes is expected to throw for 254.2 yards and score two touchdowns in this game.

Kareem Hunt leads the running backs for the Chiefs. He has rushed for 245 yards and scored four touchdowns in eight games. Hunt is projected to add 32.5 rushing yards and a touchdown in the upcoming game.

Head coach Andy Reid has guided the team to a 5-3-0 record. The Chiefs are in the AFC West division and play at Arrowhead Stadium. They have a road record of 1-2-0 this season.

Final Betting Pick

The Buffalo Bills are a solid pick for the money line at +110. They have a strong home record of 3-1 this season. Their recent win against the Panthers shows they are playing well, especially with a strong running game led by James Cook. The Bills’ defense ranks 11th in opponent score, which can help them against the Chiefs’ offense.

The under 52.5 points is a good choice due to both teams having strong defenses. The Chiefs rank 4th in opponent score, and the Bills are 11th. This suggests that scoring might be limited. With both teams focusing on defense, the total points could stay under the set line.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.