Los Angeles Rams vs Arizona Cardinals NFL Betting Prediction
PublishedDecember 3, 2025,            Posted By: Maria Uebelhor
Last updated:December 3, 2025 ,

NFL Los Angeles Rams vs Arizona Cardinals Prediction 12/7

The Los Angeles Rams will play against the Arizona Cardinals on Sunday, December 7, 2025. This game will take place at State Farm Stadium in Glendale, AZ, and kick off at 4:25 PM. Fans can watch the action on FOX. The Rams have a strong season record, while the Cardinals look to improve their home performance. Both teams are part of the NFC West division.

Rams vs. Cardinals Betting Prediction

  • Money Line Prediction: Los Angeles Rams at -417. The Rams have a strong road record of 4-2 and a better overall season record compared to the Cardinals, who have struggled at home with a 1-5 record.
  • Over/Under Prediction: Under 48.5. Both teams have shown defensive capabilities, and the Cardinals have struggled to score in recent games, making the under a safer bet.

Team Trends

  • The Los Angeles Rams have a strong season record of 9-3-0.
  • Arizona Cardinals have struggled at home with a record of 1-5-0.
  • The Rams recently lost to the Carolina Panthers with a score of 31-28.
  • Arizona Cardinals’ last game was a close loss to the Tampa Bay Buccaneers, 20-17.
  • Both teams are part of the NFC West division.

Rams vs Cardinals Preview

The Los Angeles Rams head into Week 14 with a solid 9-3 record, leading the NFC West. They aim to maintain their position at the top. Matthew Stafford, the Rams’ quarterback, is expected to pass for over 250 yards. Puka Nacua and Davante Adams will be key targets for Stafford, with both projected to contribute significantly in receiving yards.

On the other side, the Arizona Cardinals have struggled this season with a 3-9 record. They are at the bottom of the NFC West standings. Jacoby Brissett, the Cardinals’ quarterback, is projected to throw for over 220 yards. Marvin Harrison Jr. and Trey McBride will be crucial in the Cardinals’ passing game. The Cardinals look to improve their performance at home, hoping to challenge the Rams in this divisional game.

Arizona Cardinals: Team Insights and Player Projections

The Arizona Cardinals, led by head coach Jonathan Gannon, are part of the NFC West. This season, they hold a 3-9 record, with a 1-5 record at home. They play their home games at State Farm Stadium.

Quarterback Jacoby Brissett is projected to lead with 223.6 passing yards and 1.4 touchdowns in this game. The Cardinals will rely on running back Bam Knight, who is expected to contribute 31.3 rushing yards. Wide receiver Marvin Harrison Jr. might add to the offense with 55 receiving yards.

During the 2024 season, the Cardinals scored 400 points, ranking 12th. They had 3,639 passing yards and 2,451 rushing yards. Their defense ranked 14th in opponent score with 379 points allowed and managed 41 sacks.

Los Angeles Rams: A Closer Look at the Away Team

The Los Angeles Rams, coached by Sean McVay, belong to the NFC West. They currently have a strong 9-3 record this season. At SoFi Stadium, they are 5-1, and on the road, they are 4-2.

Quarterback Matthew Stafford is expected to have a solid game with 252.3 passing yards and 2.1 touchdowns. Running back Kyren Williams may contribute with 68.8 rushing yards. Wide receiver Puka Nacua is projected to gain 90.9 receiving yards.

The Rams scored 367 points in the 2024 season, ranking 19th. They achieved 3,868 passing yards, which placed them 10th, and 1,765 rushing yards, ranking 23rd. Defensively, they allowed 386 points and recorded 38 sacks, placing them 16th and 11th, respectively.

Final Betting Pick

The Rams are a strong pick for the money line at -417. They have a solid road record of 4-2, which shows they can perform well away from home. Matthew Stafford’s projected stats also support this, with over 250 passing yards and two touchdowns expected. The Cardinals have struggled at home with a 1-5 record, making the Rams a safer choice.

The under 48.5 points is another good bet. The Rams’ defense ranks well, with 13 interceptions last season. The Cardinals have had trouble scoring, especially in recent games. Their last home game against the 49ers ended with only 22 points scored by the Cardinals, indicating potential difficulties in reaching a high total score.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.