New England Patriots vs Buffalo Bills NFL Betting Prediction
PublishedOctober 1, 2025,            Posted By: Maria Uebelhor
Last updated:October 1, 2025 ,

NFL New England Patriots vs Buffalo Bills Prediction 10/5

The New England Patriots will play against the Buffalo Bills on Sunday, October 5, 2025. The game will be held at Highmark Stadium in Orchard Park, NY, and will start at 8:20 PM. Fans can watch the game on NBC. The Bills are currently leading the AFC East with a 4-0 record, while the Patriots are at 2-2.

Patriots vs. Bills Betting Prediction

  • Money Line Prediction: Buffalo Bills -402. The Bills are undefeated at home this season with a 3-0 record. Their strong offense, led by Josh Allen, makes them a solid choice.
  • Over/Under Prediction: Under 49.5 (-109). Both teams have shown solid defensive capabilities, and the Patriots have a lower scoring offense, which could keep the total points below the line.

Team Trends

  • The Buffalo Bills have a perfect 4-0 record this season.
  • New England Patriots have a 1-0 record on the road this season.
  • Buffalo Bills have won all three of their home games this season.
  • New England Patriots recently won against the Carolina Panthers with a score of 42-13.
  • Buffalo Bills won their last game against the New Orleans Saints, 31-19.

Patriots vs Bills Preview

The New England Patriots will take on the Buffalo Bills in an exciting Week 5 game. The Bills are at the top of the AFC East with a perfect 4-0 record. The Patriots are in second place with a 2-2 record. The game will be held at Highmark Stadium, and fans can catch it on NBC at 8:20 PM.

Quarterback Josh Allen leads the Bills with an impressive 242.4 passing yards projection. For the Patriots, Drake Maye is expected to pass for 216.6 yards. Rhamondre Stevenson and James Cook will be key players in the running game. Fans can expect a competitive game as these AFC East rivals meet on the field.

Buffalo Bills: A Strong Start to the Season

The Buffalo Bills have started the season with a perfect 4-0-0 record. At Highmark Stadium, they are unstoppable with a 3-0-0 home record. Sean McDermott, the head coach, leads the team in the AFC East.

Josh Allen is the standout quarterback for the Bills. In four games, he has thrown for 964 yards and seven touchdowns, with only one interception. James Cook is the top running back, rushing for 401 yards and scoring five touchdowns.

The Bills’ defense is solid, ranking 11th in opponent scores. They have recovered 16 fumbles, ranking first in the league. Injuries are a concern, with key players like Larry Ogunjobi and Matt Milano listed on the injury report.

New England Patriots: Road Warriors Ready for Action

The New England Patriots have a balanced 2-2-0 record this season. They have shown strength on the road with a 1-0-0 away record. Head coach Mike Vrabel is guiding them through the AFC East with a focused approach.

Drake Maye is the leading quarterback for the Patriots. In four games, he has thrown for 988 yards and seven touchdowns. His performance is crucial, with no interceptions, making him a reliable choice.

Rhamondre Stevenson and TreVeyon Henderson are the top running backs. Stevenson has 125 rushing yards and 11 receptions, while Henderson adds 97 rushing yards. Both players aim to make an impact against the Bills.

Final Betting Pick

The Buffalo Bills have been strong at home with a 3-0 record. Josh Allen leads a powerful offense, making them a good pick for the money line. The Patriots have a decent road record, but the Bills’ home advantage and offensive strength give them the edge.

For the over/under, taking the under 49.5 is a solid choice. The Patriots’ offense has not scored high in recent games, and both teams have good defenses. This could lead to a lower-scoring game, keeping the total points below the line.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.