The San Francisco 49ers took on the Indianapolis Colts at Lucas Oil Stadium. The game was held on Monday, December 22, 2025, at 8:15 PM. The 49ers won with a score of 48-27.

Brock Purdy led the 49ers with 295 passing yards and five touchdowns. Christian McCaffrey added to the offense with 117 rushing yards and two receiving touchdowns. The Colts had a strong effort from Alec Pierce, who caught two touchdown passes.

The 49ers took control early, scoring 14 points in the first quarter. They kept the momentum, adding 10 points in both the second and third quarters. In the final quarter, they scored another 14 points, ending with 48 points. The Colts tried to keep pace, scoring 7 points in the first quarter. They matched the 49ers with 10 points in the second quarter but only managed 3 points in the third. In the fourth quarter, they scored 7 points, finishing with 27 points. The 49ers had a strong passing game, with 5 touchdowns and 440 total yards. The Colts had a tougher time, with 312 total yards and 3 touchdowns.

Brock Purdy led the San Francisco 49ers with an impressive performance. He threw for 295 yards and five touchdowns. Purdy also added 11 rushing yards to his game stats.

Christian McCaffrey made a big impact on the ground and through the air. He rushed for 117 yards and caught passes totaling 29 yards. McCaffrey scored two receiving touchdowns for the 49ers.

Alec Pierce was a key player for the Indianapolis Colts. He had 86 receiving yards and scored two touchdowns. Philip Rivers also contributed with 277 passing yards and two touchdowns.

What’s Next

The San Francisco 49ers now hold an 11-4 record. They are second in the NFC West Division. The Seattle Seahawks are at the top with a 12-3 record. The 49ers have won their last four games. This win helps them stay close to the Seahawks. The Indianapolis Colts are now 8-7 in the AFC South Division. They rank third behind the Jacksonville Jaguars and Houston Texans. The Colts have lost their last four games. This has affected their position in the division. The head-to-head record with the 49ers shows that the Colts have won three of their last five meetings.

The San Francisco 49ers will play their next game against the Chicago Bears. This game is scheduled for Sunday, December 28, 2025, at 8:20 PM. The game will take place at Levi’s Stadium, where the 49ers will be at home.

The Indianapolis Colts will face the Jacksonville Jaguars in their upcoming game. This game is set for Sunday, December 28, 2025, at 1:00 PM. The Colts will play at home at Lucas Oil Stadium.

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