San Francisco 49ers vs Houston Texans NFL Betting Prediction
PublishedOctober 22, 2025,            Posted By: Maria Uebelhor
Last updated:October 22, 2025 ,

NFL San Francisco 49ers vs Houston Texans Prediction 10/26

The San Francisco 49ers will play the Houston Texans on Sunday, October 26, 2025. The game is set for 1:00 PM at NRG Stadium in Houston, Texas. Fans can catch the action on FOX, and the weather forecast predicts a mild day with light rain, though the retractable roof may limit its impact.

49ers vs. Texans Betting Prediction

  • Money Line Prediction: San Francisco 49ers +101. The 49ers have a strong road record of 3-1 this season. Their recent win against the Falcons shows they can perform well on the road.
  • Over/Under Prediction: Under 41.5. Both teams have shown solid defensive stats, with the 49ers ranked 8th in opponent offensive yards and the Texans ranked 6th. This suggests a lower-scoring game.

Team Trends

  • The game will be played at NRG Stadium in Houston, TX, which has a retractable roof.
  • The San Francisco 49ers have a strong road record this season with 3 wins and 1 loss.
  • Houston Texans have won 1 and lost 1 at home this season.
  • Christian McCaffrey of the 49ers had 129 rushing yards and 2 touchdowns in their last game against the Falcons.
  • C.J. Stroud of the Texans threw for 244 yards and 4 touchdowns in their victory over the Ravens.

49ers vs Texans Preview

The San Francisco 49ers are ready to take on the Houston Texans in Week 8 of the 2025 NFL season. The 49ers hold a strong 5-2 record and lead the NFC West Division. They aim to continue their success with quarterback Brock Purdy, who is projected to throw for 254.7 yards and 1.5 touchdowns in this game. Running back Christian McCaffrey is also expected to contribute with 66.3 rushing yards and 0.6 touchdowns.

On the other side, the Houston Texans have a 2-4 record and are looking to improve their standing in the AFC South Division. Quarterback C.J. Stroud is projected to throw for 213.3 yards and 1.5 touchdowns. Wide receiver Nico Collins is a key player for the Texans, with projections of 58.4 receiving yards and 0.4 touchdowns. Both teams will compete under the retractable roof of NRG Stadium, which should minimize any impact from the light rain forecasted. Fans can watch the game on FOX at 1:00 PM.

Houston Texans: A Closer Look at the Home Team

The Houston Texans are led by head coach DeMeco Ryans. This season, they have a record of 2-4-0 with a home record of 1-1-0. They play in the AFC South and have NRG Stadium as their home field.

C.J. Stroud is the starting quarterback for the Texans. He is projected to score 15.1 fantasy points in the upcoming game, with 213.3 passing yards and 1.5 touchdowns. The Texans’ wide receivers, like Nico Collins and Christian Kirk, are key targets for Stroud.

The Texans’ running game features Woody Marks and Nick Chubb. Woody Marks is expected to rush for 36.1 yards and catch 1.8 passes in the next game. On the defense, the Texans ranked 13th last season in opponent scoring, making them a tough team to score against.

San Francisco 49ers: Road Warriors Ready for Action

The San Francisco 49ers have a strong start this season with a 5-2-0 record. They are led by head coach Kyle Shanahan and play in the NFC West. Their road record is impressive at 3-1-0, showing they perform well away from home.

Brock Purdy, the starting quarterback, is projected to earn 15.9 fantasy points with 254.7 passing yards and 1.5 touchdowns. Christian McCaffrey leads the running game, expected to gain 66.3 rushing yards and catch 5.5 passes. George Kittle is a key target for Purdy, contributing 57.3 receiving yards and 0.4 touchdowns.

The 49ers’ defense ranks high, with 37 sacks and 11 interceptions last season. They face several injuries, with players like Nick Bosa and Fred Warner out. Brock Purdy is questionable for the upcoming game due to a toe injury, but he remains a vital part of the team.

Final Betting Pick

The San Francisco 49ers have shown they can win on the road with a 3-1 record this season. Their recent victory against the Falcons highlights their ability to perform away from home. Brock Purdy’s projected 254.7 passing yards and Christian McCaffrey’s 66.3 rushing yards can help the 49ers secure a win.

Both teams have strong defenses, making the under 41.5 a solid pick. The 49ers rank 8th in opponent offensive yards, while the Texans rank 6th. This suggests that the game might have fewer points, as both teams focus on limiting the other’s offense.

Football fans, this one’s for you! Action 24/7 is the only sportsbook offering the Parlay Cards for both College Football and NFL matchups. Pick your teams, lock in your bets, and score payouts that could turn $5 into $100K — or $50 into $1 Million. It’s simple, and it’s exclusive to Action 24/7. Create your College Football and NFL parlays today!

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.