Get ready for an exciting game as the San Francisco 49ers visit the Los Angeles Rams on Thursday, October 2, 2025. The game kicks off at 8:15 PM at SoFi Stadium in Inglewood, CA. Both teams have a 3-1 record this season, making this NFC West battle one to watch. Tune in on AMZN to catch all the action under the dome with clear skies and a warm breeze outside.

49ers vs. Rams Betting Prediction

• Money Line Prediction: San Francisco 49ers at +241. The 49ers have a strong road record this season, being undefeated in away games. This trend makes them a good value pick against the Rams.
• Over/Under Prediction: Under 46.5. Both teams have shown solid defensive performances recently, which could keep the total score low.

Team Trends

• The San Francisco 49ers have a perfect road record this season, winning both of their away games.
• The Los Angeles Rams are undefeated at home this season, with a 2-0 record at SoFi Stadium.
• In their last game, the Rams defeated the Indianapolis Colts 27-20 at home.
• The 49ers lost their most recent game against the Jacksonville Jaguars 26-21 at home.
• Both teams have the same overall record this season, standing at 3-1-0.

49ers vs Rams Preview

The San Francisco 49ers and Los Angeles Rams are set for a key NFC West game. Both teams hold a 3-1 record, making this game important for division standings. The 49ers lead the division with a perfect 2-0 division record. The Rams are looking to improve their standing with a win at home in SoFi Stadium.

Key players will be crucial in this game. For the 49ers, Brock Purdy is expected to pass for over 220 yards. Christian McCaffrey could add strength with 69 rushing yards. The Rams will rely on Matthew Stafford and his projected 234 passing yards. On the ground, Kyren Williams is set to rush for over 70 yards. The game will be broadcast on AMZN, with clear skies outside the dome. Fans can expect a competitive game under the lights.

Los Angeles Rams: Key Players and Season Overview

The Los Angeles Rams are having a strong season with a 3-1-0 record. Head Coach Sean McVay has led the team to an undefeated home record of 2-0-0. The Rams play their home games at SoFi Stadium in the NFC West division.

Matthew Stafford is the Rams’ top quarterback with 1,114 passing yards this season. He has thrown eight touchdowns and only two interceptions over four games. Stafford’s performance ranks him first in the team and league for passing yards.

Running back Kyren Williams has 303 rushing yards in four games. He has also scored a rushing touchdown and caught eight receptions. Wide receiver Puka Nacua leads with 503 receiving yards and 42 receptions, ranking first in the league for both categories.

San Francisco 49ers: Players to Watch and Game Insights

The San Francisco 49ers have started the season with a 3-1-0 record. Head Coach Kyle Shanahan leads the team in the NFC West division. The 49ers have a perfect road record of 2-0-0 this season.

Brock Purdy is the 49ers’ starting quarterback for the upcoming game. He is expected to pass for 222.8 yards and score 1.3 touchdowns. His recent performance has helped the team secure a good start to the season.

Christian McCaffrey is the top running back for the 49ers. This game, he is projected to rush for 69.4 yards and catch 5.5 receptions. McCaffrey’s efforts contribute significantly to the team’s offense.

Final Betting Pick

The San Francisco 49ers have not lost on the road this season. Their strong away record makes them a solid pick for the money line at +241. Brock Purdy’s passing game, with an expected 222.8 yards, adds to their chances.

Both teams have shown strong defenses in recent games. The 49ers have limited opponents to low scores, and the Rams have a solid home defense. This makes the under 46.5 a reasonable choice, as both teams might keep the score low.

Football betting just got an upgrade, Tennessee. Action 24/7 is the only sportsbook giving you a 10% College Football & NFL boost on spreads and totals every game day. Bigger odds, better payouts, and more fun — all season long, right here in Tennessee.

All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.