On Sunday, November 16, 2025, the Tampa Bay Buccaneers will play against the Buffalo Bills at Highmark Stadium in Orchard Park, NY. Both teams have a record of 6-3. The game will start at 1:00 PM and will be broadcasted on CBS. Fans can expect an exciting afternoon of football action.

Buccaneers vs. Bills Betting Prediction

• Money Line Prediction: Tampa Bay Buccaneers +209. The Buccaneers have a strong road record of 4-1 this season, which makes them a good value bet against the Bills.
• Over/Under Prediction: Under 48.0. Both teams have solid defenses, and recent games show they can keep scores lower than expected.

Team Trends

• The Tampa Bay Buccaneers have a strong road record this season, standing at 4-1-0.
• The Buffalo Bills have been solid at home with a record of 4-1-0 this season.
• Both the Buccaneers and the Bills share the same season record of 6-3-0.
• In their last game, the Buccaneers lost to the New England Patriots with a score of 28-23.
• The Bills recently lost to the Miami Dolphins, with a score of 30-13.

Buccaneers vs Bills Preview

The Tampa Bay Buccaneers and Buffalo Bills are set to meet on Sunday, November 16, 2025. Both teams hold a 6-3 record, making this game a key matchup in their respective divisions. The Bills are currently second in the AFC East, trailing the New England Patriots. Meanwhile, the Buccaneers lead the NFC South, with a strong road record of 4-1.

Quarterbacks Baker Mayfield and Josh Allen are expected to lead their teams with solid performances. Mayfield is projected to pass for 236.1 yards and 1.8 touchdowns. Allen, on the other hand, is expected to throw for 246.1 yards and 1.9 touchdowns. Fans can anticipate an exciting game as these two teams battle it out at Highmark Stadium.

Buffalo Bills: A Closer Look at the Home Team

The Buffalo Bills have a strong season record of 6-3-0. At Highmark Stadium, they hold a 4-1-0 home record. Sean McDermott leads the team as the head coach, guiding them in the AFC East division.

Quarterback Josh Allen stands out with 2,139 passing yards and 15 touchdowns. He is projected to earn 22.6 fantasy points in the upcoming game. Running back James Cook is another key player, with an impressive 920 rushing yards this season.

The Bills’ offense has scored 525 points, ranking them second in the league last season. Their defense allowed 368 points, ranking 11th. On the injury front, several players, including Shaq Thompson and Dalton Kincaid, are listed as questionable.

Tampa Bay Buccaneers: Challenges and Opportunities

The Tampa Bay Buccaneers come into this game with a 6-3-0 season record. On the road, they have been strong, winning 4 of their 5 games. Todd Bowles leads the team as head coach, guiding them in the NFC South division.

Quarterback Baker Mayfield has had a solid season with 2,192 passing yards and 16 touchdowns. He is expected to score 17.4 fantasy points in the upcoming game. Wide receiver Emeka Egbuka is a key target with 677 receiving yards and 6 touchdowns this season.

The Buccaneers’ offense scored 502 points last season, ranking 4th in the league. Their defense gave up 385 points, placing them 15th. Injuries are a concern with several players, including Chris Godwin and Haason Reddick, listed as questionable for the game.

Final Betting Pick

The Buccaneers are a strong pick for the money line at +209. Their road record of 4-1 this season shows they perform well away from home. Baker Mayfield is expected to pass for 236.1 yards and nearly 2 touchdowns, which could help Tampa Bay secure a win.

The under 48.0 points is a solid bet due to both teams having good defenses. The Buccaneers have kept opponents to lower scores in recent games. The Bills also have a defense ranked 11th in opponent scores, which may lead to a lower total score in this game.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.