NFL Outlook Week 16; Saturday, Dec. 25, 2021

There are three weeks remaining in the NFL regular season. The season has flown by, but we still have some time to capitalize on betting before the playoffs arise. Week 16 has some tremendous betting opportunities, so let’s start preparing.

Here is your Week 16 betting outlook.

Indianapolis Colts at Arizona Cardinals: Indianapolis must remain focused to win

In Week 16, the Indianapolis Colts will look to secure another huge victory in a Saturday night game against the Arizona Cardinals. The Cardinals are 10-4 but have lost their last two games. It’s fair to assume they will be focused on Christmas Day doing whatever they can to avoid a three-game slide.

The Arizona Cardinals are coming off two straight losses and will be looking to get back on track against the Colts in Week 16. Indianapolis is 10-4 and has won their last four games, but they’ll need to remain focused if they want to beat a team that’s been playing well this season.

The Colts and Cardinals have the Christmas nightcap, and it should be an epic matchup. The Colts are desperate for a win if they want to stay in the playoff picture. The Arizona Cardinals also need to clear their slate after getting beat by the Lions in Week 15.

This is a pick ’em game, but 69% of bettors like the Colts at +1.5. The money line has value in this game for both teams. The Colts are +105, and the Cardinals are -120 to win.

Expect a more focused Cardinals team and a competitive game, but also expect Indianapolis to still win. The Colts have hit a stride and their run game combined with the inevitable takeaways of the defense will give them another victory over a top team.

The total is high at 49.5, but these teams are great at taking games over. 65% of bettors like the over for the total.

* All odds provided by Action247 Sportsbook and all odds subject to change.
**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.