49ers vs cardinals nfl prediction

NFL: 49ers vs. Arizona Cardinals Prediction 12/17/2023

The San Francisco 49ers (10-3) travel to face off against the Arizona Cardinals (3-10) on Sunday, December 17th. This game will be played at State Farm Stadium in State Farm Stadium and televised on CBS. Both team’s come into this one having won their previous games. Kickoff is set for 4:05 ET.

49ers vs Cardinals

The 49ers Are Coming Off A Win

The 49ers came out on top in their last contest against the Seahawks, winning with a final score of 28-16. Even with a victory, the 49ers couldn’t cover the spread against the Seahawks, going in favored by 14.5.

Brock Purdy wrapped up the game with 368 passing yards and a passer rating of 122. Overall, he completed 19 of 27 passes.

Defensively, the 49ers intercepted the Seahawks two times and allowed 254 passing yards in total. On the ground, the team’s rush defense gave up 70 yards on 20 attempts.

Before their matchup against the Cardinals, the 49ers have an overall record of 10-3 and have won five consecutive games. In the NFC-West, San Francisco is sitting 1st.

Looking at the 49ers’ scoring margin so far, it currently stands at +13.5. This has led to an ATS record of 7-5-1. The average over/under line for San Francisco games this season is 43.4 points. Their over/under record stands at 6-6-1, with an average margin against the over/under of +1.6.

49ers Injury Report

  • Oren Burks – Knee (Doubtful)
  • Ray-Ray McCloud III – Rib (Out)
  • Charvarius Ward – Groin (Questionable)
  • Ross Dwelley – Ankle (Out)
  • George Odum – Bicep (Out)
  • Arik Armstead – Foot/knee (Questionable)
  • Javon Hargrave – Hamstring (Questionable)
  • Elijah Mitchell – Knee (Questionable)
  • Talanoa Hufanga – Knee (Out)
  • Dre Greenlaw – Hip/ankle (Questionable)
  • Cameron Latu – Knee (Out)
  • Darrell Luter Jr. – Hamstring (Questionable)
  • Drake Jackson – Knee (Out)
  • Danny Gray – Shoulder (Out)
  • Nick Zakelj – Bicep (Out)
  • Spencer Burford – Knee (Questionable)

The Cardinals Are Coming Off A Win

In their most recent matchup, the Cardinals secured a win against the Steelers, with a final score of 24-10. The Cardinals not only won straight-up but also covered the spread as 6-point underdogs.

Arizona’s offense finished with 282 yards of total offense vs. the Steelers. On third down, the Cardinals converted at a rate of 58.8%. James Conner was the Cardinals’ top rusher with 105 yards while Kyler Murray threw for 145 yards.

During week 13, the Steelers aimed to establish their ground game against the Cardinals, with 31 rushing attempts accumulating 130 yards. Overall, Arizona’s defense had given up a total of 317 yards, including 187 yards against the pass.

Heading into week 15, the Cardinals are 4th in the NFC-West on a record of 3-10. When comparing their mark to other teams in the NFC, they are 15th. So far, they have gone 2-4 at home and 1-6 on the road.

This season, the Cardinals find themselves above .500 versus the spread with a record of 7-6. Their average scoring margin for this season stands at -7.8. Against the over/under, the Cardinals have a record of 7-6. In their games, the average over/under betting line has been 43.2 points, and the games have averaged 43.2 points per contest.

Cardinals Injury Report

  • Antonio Hamilton Sr. – Groin (Questionable)
  • Pat Elflein – Hip (Out)
  • Marlon Mack – Achilles (Out)
  • Carlos Watkins – Bicep (Out)
  • Elijah Wilkinson – Neck (Questionable)
  • Kyzir White – Biceps (Out)
  • Rashad Fenton – Undisclosed (Out)
  • L.J. Collier – Bicep (Out)
  • Marquise Brown – Heel (Questionable)
  • Leki Fotu – Hand (Out)
  • Bobby Price – Undisclosed (Out)
  • Hayden Howerton – Undisclosed (Out)
  • Michael Wilson – Shoulder (Questionable)
  • Jon Gaines II – Knee (Out)
  • Starling Thomas V – Ankle (Questionable)
  • Emari Demercado – Neck (Questionable)
  • Matt Hembrough – Back (Out)

49ers Offense Breakdownarizona cardinals betting

Overall, the 49ers offense is averaging 29.2 points per game which is 3rd in the NFL. In terms of scoring on the road, the 49ers are averaging 28.7 points per contest.

Coming into this week’s game San Francisco’s passing game is ranked 3rd in passing yards. Additionally, they are positioned 30th in pass attempts, with an average of 27.9 passes per game.

On the ground, the 49ers have carried the ball an average of 29.8 times per game and currently rank 3rd in rushing yards. Their average rushing yards per attempt is 4.7.

Cardinals Offense Breakdown

Coming into week 15, the Cardinals offense is 23rd in the league at 17.7 points per contest.

In terms of passing yards, Arizona’s offense is 22nd in attempts. Their average of 172.4 passing yards per game places them 30th in the league.

The Cardinals have been running the ball an average of 26.4 times per game and currently hold the 9th spot in the league in rushing yards. Their average yards per rushing attempt is 4.7.

49ers Team Defense

The 49ers currently rank 11th in tackles for loss and 4th in sacks on the defensive side. Their opponents are averaging 15.8 points per game and 300.4 yards per contest against them.

Cardinals Team Defense

Thus far, the Cardinals’ defense has given up an average of 355.3 yards per game and 25.5 points per contest (25th). Going into this game, they’ve allowed a completion percentage of 69.9% and have surrendered 22 passing touchdowns. When it comes to run defense, they rank 29th in the NFL.

49ers vs Cardinals Trendssan francisco 49ers betting

  • Through their last ten road contests, the 49ers offense has averaged 26 points per game while allowing an average of 18. San Francisco posted an overall record of 7-3 while going 5-4-1 ATS.
  • Across their ten previous home games, Arizona has an ATS mark of 4-6. Their straight up record in these matchups was 1-9 while averaging 13 points per game.
  • Looking back on the team’s last ten games as the underdog, the Cardinals have a straight up record of 2-8. Their record vs the spread in these games was 4-6.
  • San Francisco has done well both straight up and vs the spread when favored to win the game, going 3-0 SU and 3-0 ATS in their last three games.

49ers vs Cardinals Prediction

Look for the 49ers’ offense to put together a big performance vs. the Cardinals and cover the spread as 13.5-point favorites. In their most recent game, the 49ers put up 527 yards of offense and are projected to have another above-average performance against Arizona.

After crunching the numbers, our model is pointing to this game finishing with a combined 48 points. This projection has me feeling good about taking the over at 47.5.


All odds are courtesy of Action247 Sportsbook. Good luck!!


* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.