August 21, 2021 NFL, NFL Action247 Insider, San Francisco 49ers Share this NFL San Francisco 49ers Betting Odds Preseason NFL San Francisco 49ers After a Super Bowl berth the previous season, the San Francisco 49ers were a massive disappointment in 2020-2021 with a 6-10 record. Injuries played a key factor in the Niners missing out on the postseason, with star defensive end Nick Bosa tearing his ACL in Week 2 and quarterback Jimmy Garoppolo only starting six games. If you placed a bet on the 49ers last season, San Francisco went 7-9 against the spread. On over/unders, the Niners covered both eight times. As 49ers starting QB, Garoppolo has a 22-8 record. Unfortunately for Jimmy G, that didn’t stop general manager John Lynch from going out and drafting Trey Lance with San Francisco’s third overall pick at the draft. This will be a quarterback battle that oddly reminds me of Alex Smith versus Colin Kaepernick back in the day. Smith was a consistent winner in the regular season, but Kaepernick had way more upside and that’s what Lance gives San Francisco. Whoever the starting QB might be, the 49ers got them a really good center in free agency. Six-time Pro Bowl center Alex Mack agreed to a three-year deal with the Niners in March. Veteran corner Richard Sherman wasn’t re-signed in the offseason and remains a free agent. Defensive tackle Solomon Thomas also joined the Raiders. Despite San Francisco’s horrid record last season, we can’t forget that this is a team that was a quarter away from winning the Super Bowl in 2019. The Niners still have most of their main core from that team intact, and Vegas has taken notice of that. Action 247 Sportsbook has the 49ers over/under for wins this season set at 10.5. San Francisco is +200 to win the NFC West this season, and are listed at +1400 to win Super Bowl 56. San Francisco 49ers 2021-2022 Schedule Action 247 * All odds provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.