Los Angeles Rams vs San Francisco 49ers NFL Betting Prediction
PublishedNovember 5, 2025,            Posted By: Maria Uebelhor
Last updated:November 5, 2025 ,

NFL Los Angeles Rams vs San Francisco 49ers Prediction 11/9

The Los Angeles Rams will visit the San Francisco 49ers on Sunday, November 9, 2025. The game will be held at Levi’s Stadium in Santa Clara, California. Fans can catch the action on FOX at 4:25 PM, with weather expected to be mild under broken clouds.

Rams vs. 49ers Betting Prediction

  • Money Line Prediction: Rams -193. The Rams have been strong on the road with a 3-1 record. Their recent performance against the Saints shows they can score well.
  • Over/Under Prediction: Under 49.5. Both teams have shown solid defense in recent games, and the 49ers have limited opponents at home.

Team Trends

  • The Los Angeles Rams have a strong road record this season with 3 wins and 1 loss.
  • San Francisco 49ers have performed well at home with 2 wins and 1 loss this season.
  • In their last game, the Rams defeated the New Orleans Saints 34-10.
  • San Francisco 49ers won their most recent game against the New York Giants 34-24.
  • The weather forecast for the game at Levi’s Stadium is mild with broken clouds.

Rams vs 49ers Preview

The Los Angeles Rams and the San Francisco 49ers are set to meet in Week 10 of the 2025 NFL season. The Rams hold a 6-2 record and are second in the NFC West, just behind the Seattle Seahawks. Matthew Stafford will lead the Rams’ offense, aiming to add to his 239 passing yards projection for this game.

The 49ers, with a 6-3 record, are right behind the Rams in the division. Brock Purdy is expected to start at quarterback, with a projection of 154.6 passing yards. Christian McCaffrey will be a key player for the 49ers, projected to gain 68.9 rushing yards. The game at Levi’s Stadium will be a test for both teams as they compete for division standing.

San Francisco 49ers: Key Insights for the Game

The San Francisco 49ers have a solid record this season, standing at 6-3 overall. Their head coach, Kyle Shanahan, leads the team with a focus on strong offensive plays. At home, they have won 2 out of 3 games, demonstrating good performance at Levi’s Stadium.

Brock Purdy is projected to be the starting quarterback for the 49ers in this game. He is expected to throw for 154.6 yards and one touchdown. Christian McCaffrey is the top running back, projected to gain 68.9 rushing yards with 5.6 receptions.

The team’s offense ranks high in passing yards, with a previous season total of 4,234 yards. On defense, they recovered six fumbles and intercepted 11 passes last season. However, they will be playing without key players like Nick Bosa and Brandon Aiyuk due to injuries.

Los Angeles Rams: Road Warriors

The Los Angeles Rams are led by head coach Sean McVay. They hold a strong 6-2 record this season. Playing on the road, they have been successful, winning 3 out of 4 games.

Matthew Stafford is the top quarterback for the Rams. He is set to pass for 239.0 yards and nearly two touchdowns. Wide receiver Puka Nacua might play, though he is questionable due to a rib injury.

Running back Kyren Williams is expected to gain 71.6 rushing yards. He leads the rushing attack for the Rams. Despite some injuries, the Rams aim to keep their winning momentum going.

Final Betting Pick

The Rams have been performing well on the road this season, with a 3-1 record. Matthew Stafford is expected to pass for 239 yards, which could help the Rams maintain their strong offense. Their recent games show they can score effectively, like their 35-7 win against the Jaguars.

The prediction for the game to go under 49.5 points is based on both teams’ solid defense. The 49ers have been limiting opponents at home, with a 2-1 home record. Their defensive strength could keep the game low-scoring, making the under a reasonable choice.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.