San Francisco 49ers vs New York Giants NFL Betting Prediction
PublishedOctober 29, 2025,            Posted By: Maria Uebelhor
Last updated:October 29, 2025 ,

NFL San Francisco 49ers vs New York Giants Prediction 11/2

The San Francisco 49ers will play against the New York Giants on Sunday, November 2, 2025. This Week 9 game of the 2025 NFL season will take place at MetLife Stadium in East Rutherford, NJ. The game will start at 1:00 PM and will be broadcast on CBS.

49ers vs. Giants Betting Prediction

  • Money Line Prediction: San Francisco 49ers at -153. The 49ers have a strong road record this season, winning 3 out of 5 games. The Giants have struggled overall with a 2-6 record, making the 49ers a solid pick.
  • Over/Under Prediction: Under 48.5. Both teams have had games with lower scores recently, and the Giants’ offense ranks low in scoring. This suggests a lower total score is likely.

Team Trends

  • The San Francisco 49ers have a road record of 3-2-0 this season.
  • The New York Giants have a home record of 2-1-0 this season.
  • The 49ers lost their last away game against the Houston Texans with a score of 26-15.
  • The Giants lost their last away game against the Philadelphia Eagles with a score of 38-20.
  • Christian McCaffrey of the 49ers had 129 rushing yards and 2 rushing touchdowns in their win against the Atlanta Falcons.

49ers vs Giants Preview

The San Francisco 49ers are set to visit the New York Giants at MetLife Stadium in Week 9 of the 2025 NFL season. The 49ers hold a 5-3 record, placing them third in the NFC West. They aim to bounce back after a recent loss. The Giants, with a 2-6 record, are at the bottom of the NFC East and hope to end their two-game losing streak.

Brock Purdy leads the 49ers with a projected 263.7 passing yards and 1.6 touchdowns. Christian McCaffrey is expected to contribute significantly with 81.9 rushing yards. For the Giants, Jaxson Dart is projected to pass for 204.7 yards and 1.5 touchdowns. Tyrone Tracy Jr. could add 57.5 rushing yards. Both teams will look to their key players to make an impact in this game.

Giants Prepare for San Francisco Challenge

The New York Giants are getting ready for a tough game at home. Head Coach Brian Daboll will lead the team against the San Francisco 49ers. The Giants hold a record of 2-6 this season, with a stronger performance at home, winning 2 out of 3 games.

Quarterback Jaxson Dart is expected to throw for 204.7 yards with 1.5 touchdowns. Running back Tyrone Tracy Jr. may rush for 57.5 yards and add 0.3 touchdowns. Wide receiver Wan’Dale Robinson is projected to gain 53.2 receiving yards with 0.4 touchdowns.

In their last season, the Giants’ offense ranked 28th in passing yards. On defense, they were strong in sacks, ranking 6th. Injuries are a concern, with several players, including Cam Skattebo and Malik Nabers, out for the season.

San Francisco 49ers Gear Up for New York Test

The San Francisco 49ers, led by Head Coach Kyle Shanahan, are ready for their next road game against the New York Giants. The 49ers have a 5-3 record this season, with a solid 3-2 performance on the road. Injuries are a challenge, with key players like Nick Bosa and Fred Warner out for the season.

Quarterback Brock Purdy is expected to pass for 263.7 yards and score 1.6 touchdowns. Running back Christian McCaffrey is projected to rush for 81.9 yards and add 0.6 touchdowns. Wide receiver Ricky Pearsall may gain 55.8 receiving yards, but he is questionable with a knee issue.

Last season, the 49ers ranked 4th in passing yards and 12th in rushing yards. On defense, they were 12th in sacks, showcasing a strong front. They will aim to overcome their injury woes and continue their strong division performance, holding a 3-0 division record.

Final Betting Pick

The San Francisco 49ers have a strong road record, winning 3 out of 5 games. This shows they perform well away from home. Brock Purdy is projected to pass for 263.7 yards, which could help the 49ers secure a win. Christian McCaffrey adds to their strength with 81.9 rushing yards expected.

The New York Giants have struggled with a 2-6 record overall. Their offense ranks low in scoring, which supports the prediction for a lower total score. The Giants’ recent games have also been low-scoring, making the under 48.5 a reasonable pick.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

* All odds are provided by Action247 Sportsbook and all odds subject to change. **All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk. Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.